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A 3D composite stent model, which consists of the stent, plaque, and artery wall, is generated to characterize stent transient expansion and deflection behavior using Finite Element Method (FEM) approach. Two types (flat and central-thicker) of plaque models have been employed to evaluate the geometrical effects of atherosclerotic artery on the cardiovascular stent deployment system. Simulation results...
Dental implant has been used and studied for the replacement of missing teeth for many years. It has been well known that the success of dental implant is heavily dependent on initial stability and long-term osseointegration due to optimal stress distribution in the surrounding bones. In this study, the 3D finite element analysis is used o study the stresses distribution in dental prosthesis under...
A finite element modeling was performed in order to study the glenohumeral joint. A comparison study was conducted between the healthy humerus and an uncemented prosthetic humerus. We simulated the external and internal rotation of the glenohumeral joint in order to compare the deformation, strain and stress appeared in the prosthetic humerus with the healthy one. The results show that for the external...
This paper describes the design and characterisation of a miniature single element tri-axial piezoelectric transducer made of PZT (Lead Zirconate Titanate). The transducer will be used for in-shoe force measurement. PZT is selected to replace the original transducer material P(VDF-TrFE), which is no longer readily available. The properties of PZT and P(VDF-TrFE) are compared to show that PZT provides...
This paper concerns the development and design of filtering and linearization stage of potentiometric transducer to measure human stress level based on salivary amylase activity. The design of this new way approached is implemented using Cadence OrCAD Capture CIS 15.7 software and hardware construction and troubleshooting. From the previous research, it has been found that for a sensor input range...
The aim of this paper is to investigate the mechanical effects of Botox application to muscle pathologies such as spasticity on isolated muscle model via finite element analysis. In order to determine the effect of paralyzation location three cases are chosen: Proximal half passive, middle half passive and distal half passive. Whole muscle active and whole muscle passive cases are also studied for...
In order to improve long-term durability of bioprosthetic heart valve, stress distribution of bioprosthetic heart valve leaflets with different shapes under the same load is analyzed and compared based on finite element method. Combining traditional design theories and modern design methods, we create the cylindrical, spherical, paraboloidal and ellipsoidal curved surfaces in accordance with the geometrical...
Analysis of blood biochemical parameters is an important aspect of toxicological studies in fish. Anesthetic is typically used before blood sampling to minimize injury to the fish; however, anesthetic may also act as a stressor and alter biochemical measurements. To better understand blood responses to anesthetic stress, we evaluated biochemical alterations in the blood serum of endangered Chinese...
In tissue engineering, mechanical stimuli play an important role in the cell proliferation process. This paper developed a 3D model to analyze the shear stress distribution in porous scaffold dynamically. A series of 3D scaffolds with different porosity level (60%~80%) were constructed to generate a large amount of shear stress distributions in the CFD tool. The simulations revealed that average shear...
In the united states, traumatic brain injury (TBI) is the most common cause of death in vehicular crash. Biomechanical analysis of brain tissue is necessary because the experiment cost too much and the modeling achieved the mechanical simulation in vehicular crash. In order to obtain the mechanical properties of human brain tissue, in last 35 years, people did compression, shear, and oscillatory loading...
Media perfusion bioreactor systems have been developed to culture tissue cells throughout 3D tissue engineered scaffold in vitro, which enhance the exchange of nutrients and wastes and deliver flow-mediated shear stresses to cells. Stress and strain field acting on the engineered cells is the outcome of several factors, such as characterization of the scaffold, medium flow rate and the interaction...
CD151 plays an important role in the regulation of cell migration, vascular morphogenesis, and cancer metastasis. Many of these processes are related to the strength of cell-matrix attachment. In this study, traction force microscopy (TFM) was used to determine whether knockdown of CD151 in endothelial cells would lead to a significant modification in cell-matrix adhesion. Human dermal microvascular...
Rupture of abdominal aortic aneurysm (AAA) ranks as the 13th leading cause of death in the US. Fluid Structure Interaction (FSI) analysis was conducted with the aim of strengthening the current diagnostic measures of the disease, in particular, to (i) predict the location of wall rupture, (ii) estimate the state of pathology from the calculated ruptured potential index (RPI) and (iii) predict the...
Most current elastography methods remain qualitative or display only strain information due to the inexact internal stress distribution. A more accurate result may be obtained by employing force sensors to gauge the applied vertical compression force on skin surface through the ultrasound transducer. A computationally efficient superposition algorithm based on Love's closed-form equation (SLE) is...
The research material presented in this paper is a continuation of work done in analyzing impact properties of a biomaterial found in a banana peel. Important energy absorbing characteristics, e.g., plateau stress, locking stress, deformation mode and crushing progression, collapsing mechanism, and crushing stroke of the foam filled (peel) structure are compared with the previously analyzed unfilled...
The endothelial glycocalyx (GCX) mediates flow-induced nitric oxide release via heparan sulfate (HS), but the GCX structure is unclear and the specific HS core protein(s) involved in this mechanotransduction is unknown. Our study tests the hypotheses that flow regulates GCX thickness and organization and that the HS glypican-1 core protein mediates flow-induced activation of endothelial nitric oxide...
Collagen-based biomaterials are used widely for various soft tissue repairs and augmentation, such as ligament replacements, rotator calf repair and repair of skin. Naturally derived biomaterials have several mechanical, biological, chemical, and economical advantages over synthetic constructs. Porcine-derived collagen may become increasingly important due to fears of bovine spongiform encephalopathy...
In this study, we investigated the mechanical properties of porcine aortic sinus using a three-dimensional marker measuring technique called the direct linear transformation (DLT) method. By recording pressure-inflation tests of five porcine aortic roots with the use of two cameras simultaneously, we were able to obtain stress and strain responses of aortic sinus upon applied luminal pressures and...
Medial tibial stress syndrome (MTSS) is pain or discomfort in the leg from repetitive running on hard surfaces or forcible excessive use of foot flexors. Early diagnosis is extremely critical for proper treatment and reduces complications. Quantitative ultrasound (QUS) has been widely used to assess bone quality non-invasively, it is also radiation free, repeatable, safe, relatively accurate, and...
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