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Magnetic drug targeting in the bloodstream has been intensively studied recently, but also other interesting access and transport pathways fulfill the basic conditions for this method. More recently, magnetic drug targeting has even been accomplished for aerosol application in mouse models and indicated unmistakable advantages over all currently available therapies for lung tumors and any other very...
We investigate control of the state of infection dynamics without explicit modeling of the immune system. By using constant drug dosage we prove almost global asymptotic stability of an equilibrium with assumption of zero immune system, and then by varying the drug effect we study how to drive any initial state into a region which represents desirable clinical conditions. These results can be used...
The basic virus infection model (BVIM) is widely used in the studies of the dynamics of hepatitis B virus (HBV) and HIV infections. The basic infection reproductive number of the BVIM is proportional to the number of all cells of host's organ prior to the infection. This results implies that an individual with smaller organ maybe more resistent to virus infections than an individual with a larger...
We consider a population of HIV infected patients. In resource poor environments, decision makers must allocate antiretro-viral drugs (ARVs) to patients in need of them the most. Further complicating matters is that once a patient is given ARVs, the decision maker must decide when to deny further access to ARVs. We compare various methods for determining which patients should receive ARVs and when...
Cisplatin is one of the most widely used cancer chemotherapeutic agents and is utilised to treat testicular and ovarian carcinomas as well as certain sarcomas and lymphomas. However, despite its clinical success, cisplatin treatment is still associated with a number of dose-limiting toxic side effects. The purpose of this study was to clarify the molecular events that are important in the anti-tumour...
In literature it has been mentioned that several factors are responsible for the successful accomplishment of cancer therapy. Moreover, during the course of treatment patients has undergone different physiological states. In recent time several analytical models are developed to address these issue and further progresses are in the process. This actually prompted us to develop a multi-modal reasoning...
HIV infection is one of the major health problems in today's world, especially in a developing country like India. The impact of HIV on the pediatric population is no less dreadful. Pediatric HIV is a subset of HIV which requires special attention. Efficient information management is one of the key issues in pediatric HIV treatment. Electronic health record (EHR) plays an important role in patient...
This study was comparison of MGMT and ERBB2 expression in human gliomas. RT-PCR method was used to determine the mRNA levels of MGMT and ErbB2 gene in 42 clinical glioma specimens,There was significant concordance between the expression of MGMT and ErbB2 (p < 0.01). MGMT and ErbB are highly remarkably related each other. The results suggest that there may be in relationship among MGMT and ErbB2...
Oral anticoagulation therapy, largely performed by warfarin-based drugs, is commonly used for patients with a high risk of blood clotting which can lead to stroke or thrombosis. The state of the patient, with respect to anticoagulation, is captured by the index INR, which is to be kept within a therapeutic range. The patients' response is marked by high interindividual and inter-temporal variability,...
In vitro sensitivity testing of tumor cells could rationalize and improve the choice of chemo- and hormone therapy. Microfluidic technology holds high promise to facilitate the progress of biology by enabling miniaturization and upgrading of current biological research tools due to its advantages such as low sample consumption, reduced analysis time, high-throughput and compatible sizes with most...
Adverse Drug Events (ADEs) are currently considered as a major public health issue, resulting in endangering patients' safety and significant healthcare costs. The EU-funded project PSIP (Patient Safety through Intelligent Procedures in Medication) aims to develop intelligent mechanisms towards preventing ADEs, aiming to improve the entire Prescription - Dispensation - Administration - Compliance...
In somatic gene therapy, new concepts for the transfer of DNA into specific cell nucler are of interest. In this study, the feasibility of using magnetic nanoparticles with chemotherapeutant (PEI-As2O3/ Mn0.5Zn0.5Fe2O4) as gene vector is evaluated. Mn0.5Zn0.5Fe2O4 magnetic nanoparticles(MZF-NPs), obtained through co-precipitation method, were firstly combined with As2O3 to prepare As2O3/Mn0.5Zn0.5...
Medical mistakes at creation of the process of diagnostics and therapy (further-course) can lead to the most fatal consequences for the patient. It is necessary for doctor to keep in mind the wide range of diverse factors in a context of the current status of the patient. In this report the innovative method of creation of the course of drug therapy is presented. The course is considered as the program...
Recently, superparamagnetic nanoparticles of iron oxides have shown great potential in bio-applications, including magnetic resonance imaging contrast enhancement, drug delivery, bio-separation, tissue repair, hyperthermia, and others. In this study, we have explored the enhanced cytotoxicity effect of arsenic trioxide (As2O3) on both sensitive K562 cell line and adriamycin-resistance K562/A02 cell...
This study could show that the potent inhibitor of PDE5 from Epimedium sagittatum components. The PDE 5 inhibitors of data set from Xia's study were calculated their properties. Multiple linear regression analysis was used to build the QSAR model. Those properties were associated to drug activities by the QSAR model. This result showed high correlation (R2 = 0.848) with drug activities in this QSAR...
In ovarian cancer treatment there is no single standard criterion adopted for chemotherapy responses assessment. CA-125 is widely used to evaluate chemotherapy responses and doctors experience still play an important role in the judgment of chemotherapy response. It is noted that there are cases whose CA125 values are in the same range but classified differently. The situation becomes complicated...
Sudden cardiac arrest (SCA) due to fatal cardiac arrhythmias such as ventricular fibrillation is the leading cause of death in the United States, killing 350,000 Americans each year. Thus, it is of great importance to investigate the mechanisms that can suppress abnormal heart rhythms. In this work, we study the effects of drugs such as channel blockers through mathematical modeling of cardiac electrophysiological...
Continuous monitoring of specific metabolite and drug levels within a patient's blood can contribute to shorter hospital stays and more successful treatment of both chronic and acute diseases. Intravenous microdialysis is an attractive technology for continuous venous blood sampling that can be used to manage tight glucose control and to sample a large variety of molecules from human blood. In combination...
Understanding transport and deposition of inhaled particles in the human airways plays a crucial role in the targeted therapy of pulmonary diseases, and the administration of inhaled medicines. Numerous researchers have studied the inhalation of particles using experiments or computer models. Even though experiments have shown that the airflow in the trachea and the upper branches of the lung is turbulent,...
Hypertension is a common clinical disease and a major risk to human health. Many clinical findings indicate that certain types of music can reduce blood pressure (BP), and music therapy is considered as an important part of anti-hypertension treatment. We integrate our former related research achievement into the new MP3 player, which can also detect the current BP value with a cuffless measurement...
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