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Flourescence resonance energy transfer (FRET) between CdSe quantum dots (QDs) and meso-tetraphenylporphyrin (TPP) photosensitizers is studied by two-photon excitation fluorescent spectroscopy with 800nm femtosecond laser pulses. Evident transfer results are obtained in both the steady-state and time-resolved experiments. A slight peak shift to the red region in the emission of the CdSe QDs is observed...
In the present study, we proposed a design of asymmetric planar electrodes for long-term monitoring of glucose level at body temperature. The asymmetric planar electrodes were fabricated by thin film technology on glass and cut as chip sensor. The glass-based chip sensor was further immobilized with glucose oxidase for glucose measuring. To investigate the stability of the glass-based chip sensor,...
In this paper, two methods of microscopic image analysis were presented to classify the abnormal cells in Papanicolaou(Pap) smear for cervical cancer screening. Our goal is to extract those cell nuclei which are abnormally large size, bizarre shape as well as hyper density and we hope to apply this method to the different kinds of abnormal cells. The global information of the image and the local image...
Hydroxyapatite (HA) has been widely used in clinical field because of its excellent biocompatibility. However, its poor thermal stability limits its application. In present paper, the decomposition characteristics of both nano-sized HA powder prepared by precipitation method and its sinters at the temperature from room temperature to 1500°C in the air were studied. X-ray diffractometer (XRD), High-temperature...
We developed a fast and precision immunoassay-based microfluidic assay system that consisted of a microfluidic analytic cartridge and immunoassay reagents for point-of-care testing (POCT). The nano-magnetic beads conjugated antibodies, HRP-labeled analog, and color reagent were all pre-loaded and packaged in a microfluidic analytic cartridge. The whole assay process was completed within 30 min without...
In this paper, we describes an integrated MEMS tactile tri-axial micro-force probe sensor based on piezoresistive for Minimally Invasive Surgery (MIS) as it's micro-structure, three-dimensional measurement and high resolution up to be micronewton (μN) scale. The sensor is 4 × 4 × 20.9 mm3. The sensing element of the sensor is fabricated on Silicon on Insulator (SOI) wafer by surface and bulk micromachining...
This paper presents the fabrication process of a GMR spin-valve biosensor, and discusses the general design rules of the plane structure of the biosensor. The resistance variation of the sensor is studied versus the magnetic excitation field when 1ul solution of nanoparticles (150nm in diameter) with a concentration of 25mg/ml is directly dropped on the surface of the sensor. The experimental results...
A novel and simple technique is implemented to construct the spray nozzle tips on the glass microchips with 50μm width by 20μm depth channels. The microchips are fabricated in following the conventional photolithography and glass wet etching processes. The nozzles are diced using the wafer dicing machines, which is integrated the nozzle fabrication step at the same dicing step. The chips are cut through...
The paper constructed a 3-D display system which comprised of a ball-like controller, wireless transmitter/receiver, screen and software in host computer. The hard-core of ball-like controller consists of a tri-axial MEMS geomagnetic sensor MXR9500G and a tri-axial MEMS acceleration sensor MMC3120MG afforded by MEMSIC, Inc. in Wuxi, Jiangsu. With the system, when you rotate the ball-like controller,...
A new cell culture system is demonstrated in this paper. This system includes a culture incubator with a compact optical monitoring module and an electro-chemical impedance sensor (ECIS) chip with gelatin micro patterns attracting living cells selectively. We provided a platform with a shorter observation interval of 4 hours and a finer line width of electrodes of sensor chips than the prior art in...
The paper studies the effect of the adhesive mass in the cantilever beam dynamic. In this paper, this determines the adhesive mass by using the adhesive material volume. The adhesive volume estimation is the semi-sphere volume. The adhesive volume in the cantilever beam can be determined by using the SEM (Scanning Electron Microscopy, SEM). From the analysis result, this can be found that the effect...
This study investigate the potential biomedical application of micro/nano-aperture membrane fabricated with Polytetrafluoroethylene (PTFE). Experimental work is carried out to examine the membrane's sound transmission/absorption characteristics under the condition of different aperture diameter, thickness and cavity depth of tube. It is discovered that when there is no air layer besides the tested...
Two-photon-excited fluorescence (TPEF) enhancement of a semiconductor quantum dot (SQD) adsorbed on a Au nanoparticle (NP) was investigated theoretically. Surface plasmon resonance (SPR) enhancement of the exciting light and radiative rate of the SQD, and nonradiative energy transfer (NRET) from SQD to Au NP were taken into account. Compared to the unitary enhancement factor obtained from considering...
A novel magnetic controlled navigation system is proposed for controlling endoscopic micro robot's locomotion and location in the gastrointestinal tract. The proposed approach exploits permanent magnet and mechanical movement to generate quasi-static magnetic field instead of AC alternating magnetic field, and thus can be applied to the noninvasive exploration of gastrointestinal tract with minimum...
Using Micro Electro Mechanical Systems (MEMS) technologies, we have developed the world's smallest, lightest, and least power-consuming integrated laser Doppler blood flow sensor. Unlikely commercial optical fiber type blood flow instruments, the structure of our sensor need not optical fiber, which is also invulnerable to any movements of the person wearing it. Therefore our sensor enables stable...
This study presents a detailed investigation on the effect of components of a single transducer pulse on the drop ejection process for a Picojet printhead, commercially available drop-on-demand (DOD) ink jet device. It is found in current results that the volume of the primary drop is closely related to the maximum displacement, Df of chamber wall induced by piezoelectric transducer in forward stage,...
The purpose of this paper is to study the heavily boron-doped effect on the etch rates of boron-doped <;111> single-crystal silicon in different TMAH solutions. The boron atoms were heavily doped in <;111> single-crystal silicon by using diffusion process. We change the pre-deposition time and annealing time of diffusion process to form different concentration distributions. The samples...
This study managed to generate UV-crosslinking microparticles and wrapped in the microcapsules by using an ultrasonic vibration microfluidic chip, and we had demonstrated that the UV-crosslinking microparticles is real wrapped in the microcapsule and the microcapsules size was able to be controlled by altering the flow rate of the wrapped and sheath phase. Through control this experiment conditions...
This project presents a method to model a single channel from protein sequences provided by common protein sequences databanks. Under single-cell level, concrete protein structures will provide a configuration to simulate structural mechanics. Here a potassium was modeled, voltage-gated channel (Kv channel), to investigate its corresponding mechanics of each subunit. In electrophysiology, the potassium...
Traditional identification methods of pathogenic Candida albicans are time-consuming due to the long-term incubation. The purpose of this study is to develop a noninvasive biomolecular sensing technology for rapid identification of Candida albicans. Surface enhanced Raman scattering (SERS) based on colloidal sliver was used to rapidly detect specific molecules on the surface of cells cultured on SDA...
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