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The current approach to postmarketing surveillance primarily relies on spontaneous reporting. It is a passive surveillance system and limited by gross underreporting (<;;10% reporting rate), latency, and inconsistent reporting. We propose a new interestingness measure, causal-leverage, to signal potential adverse drug reactions (ADRs) from electronic health databases which are readily available...
The purpose of the work described in this paper is to assess the identification of a neuromuscular blockade model using the data obtained from the response of the first bolus during a general anesthesia. The aim is to use the identified model to help on the selection of a controller to be used during neuromuscular blockade control. The identification methodology explores the structure of the nonlinear...
Computational structure prediction, including de novo and homology modeling, is an important tool for membrane protein studies. Developing an accurate scoring function that can be used for structure discrimination and assessment remains a challenge. In our previous work, we have analyzed a set of high-resolution membrane protein structures using the network approach developed in our lab and proposed...
Based on the pharmacokinetic model of conventional agents, through introduction of sustained-release effect factor, we build a pharmacokinetic model of sustained-release agents so as to provide a new model of agents for clinical application. We discuss the properties of the new model and make a comparison with the conventional ones. By theoretical analysis and clinical data validation of metformin...
Summary form only given. Molecular dynamics (MD) simulation has long been recognized as a potentially transformative tool for understanding the behavior of proteins and other biological macromolecules, and for developing a new generation of precisely targeted drugs. Many biologically important phenomena, however, occur over timescales that have previously fallen far outside the reach of MD technology...
We consider the problem of similarity search in applications where the cost of computing the similarity between two records is very expensive, and the similarity measure is not a metric. In such applications, comparing even a tiny fraction of the database records to a single query record can be orders of magnitude slower than reading the entire database from disk, and indexing is often not possible...
Abnormalities in cardiac repolarization have been implicated in cardiac arrhythmogenesis caused by disease, mutations and drugs. Of particular concern for regulatory agencies, pharmaceutical industry and society is the fact that certain drugs, in particular those not designed to affect the heart, can exhibit cardio-toxicity (i.e.unwanted side effects), which can put patients at risk of developing...
The use of experiments for studying cardiac arrhythmias, the effect of drugs, or pathologies on cardiac electrophysiology is very limited. This has made mathematical modeling and simulation of heart's electrical activity a fundamental tool to understand cardiac behavior. In this study several modifications were introduced to a recently proposed human ventricular cell model. Four stimulation protocols...
Data provided by THEW was used to test QT gender differences. Three QT/RR models were used during analysis: a transfer function model (TRF), a model based on exponential weighting of RR intervals (EXP), and an EXP model with additive direct coupling with RR intervals (EXPDC). Data from 81 men and 73 women was analyzed. Women have a significantly higher QTc (p<;10-6), steeper GainL (QT/RR slope,...
The three-dimensional structure of bovine serum albumin (BSA) was obtained successfully with the homology modeling method. The reasonable results were presented: In the nine conservative areas, the desired Root-mean-square (Rms) value (0.0001) was obtained; 17 disulfides were added into the BSA successfully; In the loops construction, the score of loops was higher than 85 with composer module evaluation,...
Drug bioavailability is a major failing point of new pharmaceuticals i.e. drugs fail to reach their target or fail to stay there long enough for therapeutic effect. Compounding this issue, significant variability exists between patients and how they metabolize and distribute a drug. We present WebPK, a web-based tool for simulation of custom pharmacokinetic models. Model parameters can be entered...
Target Controlled Infusion (TCI) systems are based in drug Pharmacokinetic (Pk) and Pharmacodynamic (Pd) models implemented in an algorithm to drive an infusion device. Several studies had compare manual titration of anesthesia and TCI system use; some studies evaluate the performance of the control algorithms for TCI systems, and a considerable number of studies assess the performance of Pk/Pd models...
QT prolongation is the only clinically proven, yet insufficient, electrocardiogram (ECG) biomarker for drug-induced cardiac toxicity. The goal of this study is to evaluate whether JT area, i.e., total area of the T-wave, can serve as an ECG biomarker for drug-induced cardiac toxicity using both signal processing and computational modeling approaches. An ECG dataset that contained recordings from patients...
We have developed a novel adaptive multi-infusion advisory system for circulatory management of critically ill patients which co-ordinates infusion adjustments to ensure safe trajectories. This system should reduce patient hospital stay and improve patient outcome by enhancing the quality of patient circulatory control; alleviating the clinical cognitive load, giving staff more time for direct patient...
Purkinje fibres play an important role in cardiac conduction and have been implicated in arrhythmia in presence of diseased states, genetic mutations, or adverse side effects of drugs. For these reasons, the Purkinje assay is commonly used in pre-clinical in vitro drug assessment of arrhythmic risk. Several investigators have pointed out that rabbit Purkinje cells, compared to other species, have...
In literature it has been mentioned that several factors are responsible for the successful accomplishment of cancer therapy. Moreover, during the course of treatment patients has undergone different physiological states. In recent time several analytical models are developed to address these issue and further progresses are in the process. This actually prompted us to develop a multi-modal reasoning...
An in-vivo body network is an interconnection of implanted medical devices without a wired or wireless connection. In this paradigm, the body's own circulatory network is utilized as the channel. Instead of electrical or electromagnetic signals, inert nano particles are used as the signal carrier. A framework for in-vivo communication along with a computer based model is developed. Simulation results...
Diabetes is a common disease, and one in which the patient has to undergo many lifestyle changes. In this paper we propose a model in which fuzzy logic can be used to determine the amount of insulin to be dosed to a diabetic, without the person having to calculate the same every half hour. Such systems have already been proposed, and we have worked based on already existing papers. This system uses...
In chemoembolization, chemotherapy drugs and thrombotic agents are directly injected into the liver tumor through a catheter navigated to the artery that supplies the tumor. In order to help surgeons to train their hand-eye coordination skills to reduce the risk of injecting the thrombotic agents incorrectly and deprive normal tissue of its blood supply, this paper proposes a method for rendering...
The adequate and rational drugs selection is considered one of the main objectives in Hospital scenarios. The drugs evaluation for their inclusion in the Hospital Pharmacy requires considering multiple evaluation aspects and criteria where different people are involved with different roles, valuations and preferences with the aim of analyzing a great number of factors and characteristics from a huge...
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