Serwis Infona wykorzystuje pliki cookies (ciasteczka). Są to wartości tekstowe, zapamiętywane przez przeglądarkę na urządzeniu użytkownika. Nasz serwis ma dostęp do tych wartości oraz wykorzystuje je do zapamiętania danych dotyczących użytkownika, takich jak np. ustawienia (typu widok ekranu, wybór języka interfejsu), zapamiętanie zalogowania. Korzystanie z serwisu Infona oznacza zgodę na zapis informacji i ich wykorzystanie dla celów korzytania z serwisu. Więcej informacji można znaleźć w Polityce prywatności oraz Regulaminie serwisu. Zamknięcie tego okienka potwierdza zapoznanie się z informacją o plikach cookies, akceptację polityki prywatności i regulaminu oraz sposobu wykorzystywania plików cookies w serwisie. Możesz zmienić ustawienia obsługi cookies w swojej przeglądarce.
Post-translational modifications (PTMs) of his tone proteins play critical roles in establishing functionally separated domains on chromatin and regulating important biological processes, such as transcription. These modifications often act in cooperative manner, forming complicated "histone codes". Elucidation of functional relationships among them will, therefore, significantly increase...
A variety of systems exist in which annotations are available at various levels of granularity to a reference coordinate system, such as roads and landmarks on a map, features within a 2-dimensional or 3-dimensional image, or genetic entities (GEs) mapped to a reference genome. As the number of annotations grows, methods to efficiently locate overlapping entities within a specific interval of interest...
The Basic Local Alignment Search (BLAST) is one of the most widely used bioinformatics programs for searching all available sequence databases for similarities between a protein or DNA query and predefined sequences, using sequence alignment technique. Recently, many attempts have been made to make the algorithm practical to run against the publicly available genome databases on large parallel clusters...
To help the biomedical scientist pre-confirm the disease-related genes, we considered these gene as a whole research set and analyzed the topological features of their interaction network. Two strategies had been proposed to construct the disease-related gene network from the OMIM database. Using these two constructed sets, we trained two support vector machine prediction models, the accuracy of which...
An essential element of a biometric system is the human machine interface (HMI), both from the user (administrator) and subject perspectives. The HMI has a significant impact on the performance of the system, as it is a key factor in the quality of the biometric sample collected. This paper will consider the implications of the HMI from the user perspective, analyzing the results of user experiences...
In recent years, with the implementation of Human Genome Project and the International HapMap Project as well as the high-throughput technology, Genome-Wide Association Study (GWAS) has been developing rapidly. Using this technology, researchers have found a series of related-genes or mutations associated with complex diseases. Psoriasis is a common clinical chronic inflammatory skin disease with...
The pace of technology has allowed classification of feature-subset of methylated and unmethylated of CpG islands of DNA sequence properties. As methylation of CpG islands is involved in various biological phenomena and function of the DNA methylation is correlated to various human diseases such as cancer, analysis of the CpG islands has become important and useful in characterizing and modelling...
Allelic DNA aberrations across our genome have been associated with normal human genetic heterogeneity as well as with a number of diseases and disorders. When copy-number variations (CNVs) occur in gene-coding regions, known relationships between genes may help us understand correlations between CNVs. However, a large number of these aberrations occur in non-coding, extragenic regions and their correlations...
This paper shows a graph based method to analyze proteomic expression data. The method allows the prediction of the expression of genes not measured by the gene expression technology based on the local connectivity properties of the measured differentially expressed gene set. The prediction of the expression jointly with the stability of this prediction as a function of the variation of the initial...
This study proposes a novel CNV detection algorithm based on scale space filtering. It uses Gaussian filter for the convolution with a scale parameter. The range of the scale parameter is adjusted according to the coverage level of read data. The position of a CNV region is determined through a coarse and a fine searches over the scales. The results showed low dependency of the performance of the...
Phenotypic comparison may provide crucial information for obtaining insights into molecular interactions underlying various diseases. However, few attempts have been made to systematically analyze the phenotypes of hereditary disorders, mainly owing to the poor quality of text descriptions and lack of a unified system of descriptors. Here we present a secondary database, PHENOMIM, for translating...
The goal of this work is to design and develop an Information System that integrates human genome variation data currently scattered in different repositories. The continuous and increasing interest generated around the variations knowledge, makes the study of this research topic from an Information System point of view extremely attractive. The system has been developed following a conceptual-model...
The majority of cellular functions can rarely be attributed to a single protein, gene or enzyme. Protein-protein interactions are fundamental to most of cellular processes or functions. Hubs, proteins with high connectivity, mediate the organization and function of cellular protein interaction networks (PINs). As a first step, research on hub proteins starts with classification. Although there are...
Social networking sites employ recommendation systems in contribution to providing better user experiences. The complexity in developing recommendation systems is largely due to the heterogeneous nature of social networks. This paper presents an approach to friend recommendation systems by using complex network theory, cognitive theory and a Pareto>optimal genetic algorithm in a two>step approach...
A music generation system using evolutionary algorithms and recurrent neural networks as the fitness evaluator is developed. The music generation process is fully automatic and requires no human interaction during the evolution phase. A data set which contains samples from The Beatles is used to train the neural network. Software for experimental purposes is developed and executed with different data...
The biological function of RPD3/HDA1 HDACs family from Physcomitrella patens was investigated by using bioinformatics. The results showed that the members of RPD3/HDA1 HDACs family were localized in different subcellular localization of P. patens, and their encoding proteins all have four sites, such as the protein kinase C phosphorylation site, the Casein kinase II phosphorylation site, the N-glycosylation...
The value of currently available services and data resides not only in the information and knowledge they bring, but also in how they can be effectively integrated to infer new knowledge. With the growth in size of such data, integration and search become computational intensive tasks; planning and optimization of the way in which joined combinations are extracted is required to obtain results and...
Podaj zakres dat dla filtrowania wyświetlonych wyników. Możesz podać datę początkową, końcową lub obie daty. Daty możesz wpisać ręcznie lub wybrać za pomocą kalendarza.