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Global outbreaks of human influenza arise from influenza A viruses with novel Hemagglutinin (HA) molecules to which humans have no immunity. So understanding of the origin and evolution of HA genes is of particular importance. Here, genomic signatures of the HA protein in different hosts was identified and associative classification for host-typing was conducted. We therefore conducted multiple-sequence...
Drug-delivery to the brain is a significant challenge due to the presence of the formidable blood-brain barrier (BBB). Current therapeutic interventions to treat brain disorders include surgical implants or catheters, both of which are highly invasive and carry the risk of long term neurological damage. In contrast, non-invasive strategies based on endogenous transport pathways in the brain are attractive...
Duchenne muscular dystrophy (DMD) is a lethal muscle disorder characterized by mutations in the DMD gene. These mutations primarily disrupt the reading frame, leading to an absence of functional dystrophin protein. Exon-skipping through the use of antisense oligonucleotides has served as a promising therapeutic approach for DMD, and clinical trials in DMD patients are currently underway. Recently,...
Early perfusion is essential for survival and function of engineered tissues. A promising solution to this problem is the development of stable microvessels within an engineered construct. Transplantation of human endothelial cells within protein gels has been shown to form functional vascular networks both in vitro and after implantation into immunodeficient mice. Co-transplantation of human pericytes,...
This poster reports the preliminary results of an on-going near infrared spectroscopy (NIRS) study conducted to examine cortical response to visual motion typically found in Virtual Reality (VR) applications. Comparing to watching a grey background, navigating through a virtual tunnel increased levels of oxygenated haemoglobin in visual cortex (around area V3). Potential benefits of the finding for...
The ageing of the European population continues to advance and will become one of the key driving forces of societal change in the decades ahead. The specific needs of an older generation for new affordable biopharmaceuticals such as monoclonal antibodies (mAbs) to treat age-and prosperity-related diseases such as Alzheimer, cancer, or rheumatism, will increase considerably, reinforcing the demand...
Stem/progenitor cells hold a great promise for application in several therapies due to their unique biological characteristics. With the purpose of harnessing these cells full potential in cell-or gene-based therapies it might be advantageous to enhance some of their features through gene delivery strategies. Accordingly, we are interested in developing efficient and safe methodologies to genetically...
Many protein complexes prediction approaches are based on the assumptions that (i) protein complexes have dense protein-protein interactions (PPI) among their subunits, and (ii) high functional similarity for the subunits. We suggest to investigate those assumptions by studying the subunits' interaction topology and sequences identity. Such consideration can possibly provide better insights for our...
Following the success of therapeutic recombinant proteins, monoclonal antibodies (mAbs) represent the second outbreak of innovation created by the biotechnology industry. With more than 25 products in clinical use worldwide, including eight blockbuster drugs, mAbs remain one of the most exciting and promising areas within the world pharmaceutical market, with a global share worth $55 billion in 2010...
The Human Protein Atlas (HPA) is a repository of location patterns of about 11000 proteins within tissues and cell lines. In this work we summarize some of our current work on analyzing immunohistochemical images of proteins within 7 distinct tissues. Firstly, we present our efforts to analyze spatial point patterns of protein staining and determine protein subcellular location from image-derived...
Non-contact, non-invasive monitoring of hemodynamic parameters has long been deemed to be important to medical monitoring in a variety of environments. Radio Frequency Impedance Interrogation (RFII) measures hemodynamic function via resonance frequency coupling to a hydrophilic protein molecule. We examined the use of RFII for hemodynamic monitoring of human subjects during Lower Body Negative Pressure...
Influenza is one of the most important emerging and reemerging infectious diseases, causing high morbidity and mortality in communities (epidemic) and worldwide (pandemic). Here, Classification of human vs. non-human influenza, and subtyping of human influenza viral strains virus is done based on Profile Hidden Markov Models. The classical ways of determining influenza viral subtypes depend mainly...
By directly measuring human soluble blood samples by Fourier transform infrared spectroscopy (FTIR) and attenuated total reflection (ATR) technology, the rapid quantitative analysis method for human hemoglobin (HGB) was established. The optimization of Savitzky-Golay (SG) smoothing modes combined with partial least squares (PLS) factor was applied to optimize the model of FTIR/ATR spectroscopy analysis...
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