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Recent studies have demonstrated that the expression of aquaporin1 (AQP1) in endothelia cells played important roles in cell migration, and migration-associated cell function such as wound healing, and neutrophil motility. In the present study, we provided evidence that AQP1 expression in vascular endothelia cells (VECs) during angiogenesis was associated with MRTF-A. Morphology and immunofluorescence...
The aim of this study is to explore the mucosal and systemic antibody immune responses induced by recombinant L.casei expressing the major immunoprotective antigen VP7 of bovine rotavirus (BRV). Two inducible expression vectors containing the antigenic dominant region of VP7 gene, pPG-1-VP7 (cell-surface expression vector) and pPG-2-VP7 (secretory vector), were constructed and electrotransformed into...
Cyclophosphamide (cy) was used to produce immunosuppressed model mice by intraperitoneal injection. Affusing different-dosage of the female silkworm moth powder, thymus and spleen index, peritoneal macrophage phagocytosis, lymphocyte transformation, serum hemolysin of mice were investigated. The result showed that all the indexes of the tested immunosuppressed mice were improved by the female silkworm...
CCAAT/enhancer binding proteins (C/EBPs) comprise a family of transcription factors that are critical for normal cellular differentiation and function in a variety of tissues. They are not only involved in normal processes of physiological metabolism but also are related to the occurrence and development of many kinds of disorders. C/EBPs have multiple modes in which they act as activators or inhibitors...
In this paper, the antioxidant activity of black glutinous corncob pigment (BGCP) on D-galactose-induced aged mice is described. The animals were divided into five groups: (1) aged group; (2) normal group; (3) low dose group; (4) medium dose group; and (5) high dose group. After 35 days, the mice were killed and the following parameters were measured in the serum, brain, and liver: malondialdehyde...
Lipoprotein lipase (LPL) of Tianfu meat goose was cloned and sequenced using a RT-PCR approach. The nucleotide sequence covered 468 bp with an open reading frame of 155 amino acids. Alignment analysis indicated that the nucleotide sequences are highly conserved to other species studied including chicken, domestic guinea pig, house mouse, Norway rat, cattle, cow and goat, and the homologies are 92...
Mitochondria are a vital organelle of eukaryotic cells. Many diseases are caused by the mitochondrial gene mutation , therefore, there is an urgent requirement to explore the proteins of mitochondrion. In this paper we have created a list of 1086 human mitochondrial genes by combining 13 datasets from publications or genomic experiments. Then we created a functional linkage network among mitochondrial...
Apoptosis is a form of genetically programmed cell death, which plays a pivotal role in normal development and the maintenance of homeostasis of a variety of tissues including cardiovascular system. Apop-1 is a soluble protein consisting of 194 amino acids with a mitochondrial localization signal at its N-terminus. RT-PCR data revealed that Apop-1 is expressed in all the organs tested. Immunofluorescence...
This paper mainly studies the anti-fatigue function and the mechanism of Epimedium flavones. The changes of the relative laboratory parameters in exercise fatigue were observed and the mechanism of resisting exercise fatigue of Epimedium flavones was discussed by using loaded swimming experiment of mice. The main contents are as follows: (1) Studying the effects of Epimedium flavones on the body weight...
Recently, various lasers therapies have been employed in clinical practice. And the lasers which relied on their wide clinical applications in treating cutaneous diseases and performing cosmetic procedures have developed greatly. The effects in treatment of laser treatment depend on the immediate response of incident light irradiated in tissues and then the subsequent tissue regeneration and remodeling,...
Alpha-fetoprotein (AFP) is a major serum protein (Mr, =70,000) synthesized during fetal life. Reappearance of AFP in adult serum often signals pathological conditions, particularly hepatocarcinomas and teratocarcinomas. To obtain monoclonal antibodies against AFP for further study of the structure and biological function of AFP, a novel method for making hybridoma cell lines producing monoclonal antibodies...
Alignment analysis indicated that the nucleotide sequences of Liver X receptors α (LXRα) of Landes goose are highly conserved to other species including chicken, human, rat, mouse and cattle, and the homologies are 95.2%, 76.3%, 74.5%, 74.3% and 74.9%, respectively. Furthermore, molecular phylogeny analyses have shown that LXRα were divided into two main evolution branches, one was the mammals branch,...
Though the functional relationship analysis for gene products is useful, a convenient and user- friendly tool to measure the functional similarity for genome-wide gene products in multiple species is still not available. We computed the functional similarity of gene products in genome wide in human, mouse and rat based on our algorithm. Database and web services were built based on the precomputed...
We investigate the effects of anti-Fas ribozyme on Fas expression and apoptosis in primary cultured Neonatal mouse ventricular myocytes. Neonatal mouse ventricular myocytes were isolated by using collagenase irrigation. A hammerhead ribozyme targeting the Fas mRNA was constructed, and transfected into Neonatal mouse ventricular myocytes via Effectene. Then Fas expression in Neonatal mouse ventricular...
Glass slides were modified with (3-aminopropyl)-trimethoxysilane, glutaraldehyde, poly-L-lysine to fabricate protein microarrays. Evaluate and choose more optimal surface modification methods for the preparation of protein microarray. The proteins probe labeled by Cy3 was immobilized onto the activated glass slides, attachment rate was evaluated. Subsequently, the mouse IgG were printed on the modified...
The liver, being the major site of metabolism, plays a critical role in xenobiotic biotransformation and clearance. Quantifying the links between central hepatic and xenobiotic metabolism is critical to understanding toxicant-induced hepatic injury. Conazoles are a class of azole fungicides used to prevent fungal growth in fruits, vegetables and seeds, and for the treatment of fungal infections. Certain...
Duchenne muscular dystrophy (DMD) is a recessive X-linked form of muscular dystrophy and one of the most prevalent genetic disorders of childhood. DMD is characterized by rapid progression of muscle degeneration, and ultimately death. Currently, glucocorticoids are the only available treatment for DMD, but they have been shown to result in serious side effects. The purpose of this research was to...
Mild traumatic brain injury (mTBI), or concussion, is one of the most common forms of injury sustained throughout Operations Iraqi Freedom and Enduring Freedom. Diagnosis is difficult for many of the symptoms are very common and may not manifest themselves immediately after the injury. Many studies on blast-related mTBI have been published from research regarding the current war in Iraq and Afghanistan...
We present a global clustering approach to identify putative intergenic non-coding RNAs based on the RNA polymerase II and Histone 3 lysine 4 trimethylation signatures. Both of these signatures are processed from the digital sequencing tags produced by chromatin immunoprecipitation, a high-throughput massively parallel sequencing (ChIP-Seq) technology. Our method compares favorably to the comparison...
SET and MYND domain-containing protein 3 (SMYD3) is a novel histone methyltransferase involved in human carcinogenesis. To establish the transgenic cell model of SMYD3 for the further studies on the characteristics and functions of SMYD3, in the present study, the human SMYD3 gene was subcloned into pIRES2-EGFP eukaryotic expressing vector. The recombinant plasmid was transfected into NIH3T3 cells...
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