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The DDK syndrome is known as the polar-lethal embryonic death that occurs at the morula-blastocyst stage when female mice of the DDK strain are mated with males from many other inbred strains (alien males). Embryonic death is interpreted to be caused by incompatibility between a DDK oocyte factor and the product from male pronucleus, both of which map to the Om locus on mouse chromosome 11. We compared...
Two novel acid mucopolysaccharides were isolated from the viscera of Haliotis discus hannai, which were cultivated in Jiaonan county Shandong Province, by protease-hydrolysis combing CPC precipitated and purified to homogeneity by DEAE 52 and Sephacryl-S 200.The acid polysaccharides obtained, named as AVAP I and AVAP II, have an average molecular weight (MW) of 10.9 KD and 32.5 KD determined by HPLC...
For raising the antigenicity of Mycobacterium bovis single antigen, fusion protein of two genes was acquired. The DNA fragments of mpb83 and ag85b were fused by splicing by overlapping extension (SOE) polymerase chain reaction(PCR), and the fusion gene mpb83-ag85b were cloned into pMD18-T vector, then we got the recombinant plasmid pMD-83-85b. pMD-83-85b and pET28a(+) were digested by BamH I and EcoR...
In order to study the biological characteristics of swine chemokine and the effect of Interferon-inducible Protein (IP-10) on the immunocompetence of vaccine, swine IP-10 gene was amplified from Spleen by RT-PCR, and the fragment was cloned into the eukaryotic expression plasmid to construct recombinant plasmid pcDNA3.1-IP-10. Then the plasmid pcDNA3.1-IP-10 was transfected into HEK293T cell. The...
The mammalian target of rapamycin (mTOR) is an important controller of cell proliferation. RAD001 (everolimus) is a specific inhibitor of mTOR, can block mTOR signaling pathway. The purposes of this study are to explore the inhibitory effects of RAD001 on Cashmere goat fetal fibroblasts (GFb cells) proliferation. We examined both the effects of RAD001 on cell proliferation and cytostatic effect of...
Summary form only given. Ferritin is a family of proteins found in different forms in most living organisms. Each ferritin is made up of 24 subunits, which self-assemble to form a cage-like nanostructure, with external and internal diameters of 12 and 8 nm, respectively. This unique architecture provides two interfaces-one outside and one inside-for possible functional loading. These interesting features...
Collagen is believed to be one of the principal load bearing components of skin. This implies that deformation of collagen microfibrils play an important role in determining the extent of skin deformation under applied loads. We have developed a novel technique for generating internal strain maps of bundles of collagen microfibrils in the skin. The technique relies on digital image correlation (DIC)...
Duchenne muscular dystrophy (DMD) is a lethal muscle disorder characterized by mutations in the DMD gene. These mutations primarily disrupt the reading frame, leading to an absence of functional dystrophin protein. Exon-skipping through the use of antisense oligonucleotides has served as a promising therapeutic approach for DMD, and clinical trials in DMD patients are currently underway. Recently,...
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