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We present CoSBiLab BlenX as a development and analysis platform for modeling pharmacodynamical systems. Together with its supporting tool CoSBiLab KInfer for inferring kinetic parameters, BlenX provides an effective compromise between the differential equations-based and mechanisms-based approaches to modeling of pharmacodynamical systems. In this paper, we support this claim with models that describe...
This paper presents a multi-drug chemotherapy scheduling method for cancer treatment using multi-objective optimisation technique. Cancer cells, very often, grows resistance to a drug if it is administered alone for a long time and drug resistance eventually causes failure to treatment in most cases. The adaptation of multi-drug treatment in cancer increases the drug performance by reducing the drug...
Electroporation is an elegant technique used for proliferation control in Cancer cells. This budding mode of therapy called electrochemotherapy uses electrical pulses and chemodrugs to trigger cell death in cancerous cells. The efficacy of this technique depends on a variety of factors including electric field intensity, pulse duration and the number of pulses. In this study, Human cervical (ME180),...
Cancer treatment by chemotherapy involves multiple applications of toxic drugs over a period of time. Optimising the schedule of these treatments can improve the outcome for the patient. A schedule of treatment and its effect on the tumour can be simulated by a mathematical growth model. However, when used in conjunction with a black-box optimisation algorithm such as an Evolutionary Algorithm (EA)...
In this paper, optimal drug schedule for patients in progressive cancer phase who take the drug through infusion pump is obtained. An objective of control is reducing tumor cell numbers effectively while minimizing total amount of drug regimen. This is done because of the known serious side effects and major damages resulting from chemotherapy. Chemotherapy brings about weakness of the patient's immune...
AIM Vaccaria segetalis was reported anti-tumor action in vitro. In this study, the effect and mechanism of inhibiting tumor growth and improving the quality of life of Vaccaria segetalis on mouse inoculated H22 solid carcinoma were investigated. METHODS The solid carcinoma model of mouse was made by H22 cells subcutaneous injection and they were divided into four groups including model control group,...
The development of a more precise targeted delivery system is critical for the advancement of cancer chemotherapy. In this study, we evaluated the effects of RGD-conjugated poly (lactic acid-co-lysine)-(Arginine-Glycine-Aspartic) nanoparticles (PLA -PLL-RGD NPs) on targeted drug delivery for BACP-37 breast cancer. PLA-PLL-RGD NPs were prepared by using the emulsion method. A subsequent MTT assay indicated...
Cisplatin is one of the most widely used cancer chemotherapeutic agents and is utilised to treat testicular and ovarian carcinomas as well as certain sarcomas and lymphomas. However, despite its clinical success, cisplatin treatment is still associated with a number of dose-limiting toxic side effects. The purpose of this study was to clarify the molecular events that are important in the anti-tumour...
In literature it has been mentioned that several factors are responsible for the successful accomplishment of cancer therapy. Moreover, during the course of treatment patients has undergone different physiological states. In recent time several analytical models are developed to address these issue and further progresses are in the process. This actually prompted us to develop a multi-modal reasoning...
This study was comparison of MGMT and ERBB2 expression in human gliomas. RT-PCR method was used to determine the mRNA levels of MGMT and ErbB2 gene in 42 clinical glioma specimens,There was significant concordance between the expression of MGMT and ErbB2 (p < 0.01). MGMT and ErbB are highly remarkably related each other. The results suggest that there may be in relationship among MGMT and ErbB2...
This paper introduces a method for cancer prediction based on the Fister-Panetta (FP) model for cancer growth.The FP equation includes a component for the tumor growth which describes its natural evolution without any treatment.The second component of the FP equation is represented by the contribution of the treatment scheme. Our prediction uses these two components to predict the evolution of the...
With the application of the immune enzyme assay, the inhibitory effects of Chinese herbal effective fractions on the expression of Epstein-Barr virus (EBV) early antigen in Raji cell have been investigated. The test result shows that astragalus polysaccharide (AP), ganoderma lucidum polysaccharide (GLP) and epimedium polysaccharide (EP) have inhibitory effects in certain range of dose. AP and GLP...
The nightshade (Solanum nigrum Linn.) has been widely used in Chinese traditional medicine as a remedy for the treatment of digestive system cancer. The anti-tumor activity of solanine, a steroid alkaloid isolated from the nightshade has been demonstrated. To observe the effect of antitumor and mechanism of solanine. The MTT assay was used to evaluate the IC50 on the 3 digestive system tumor cell...
The aim of this paper is to explore the relativity between tumor and kidney damage. This method presents the pathogeny, nosogenesis, clinical manifestation, treatment and prognosis of kidney damage what is resulted from tumor in addition to kidney through two cases of clinical data about patient suffering from kidney damage associated with tumor. It is concluded that there is a certain inherent link...
To construct a recombinant vaccine alpha-fetoprotein (AFP)-heat shock protein (HSP70) complex, and study its ability to induce specific cytotoxic T lymphocyte (CTL) response and its protective effect against AFP-producing tumor. A recombinant vaccine was constructed by conjugating mouse heat shock protein 70. By way of intracutaneous injection, mice were primed and boosted with recombinant vaccine...
With the advance of immunology, immunogene therapy is becoming a possible therapeutic alternative to advanced cancer. The aim of tumor immunogene therapy is to enhance the immune response to tumors. Evidence suggests that CD80 (B7-1) and Interferon-gamma (IFN-gamma) play important roles in antitumor immunity induced by T lymphocyte. To study the antitumor immune effects of lung carcinoma vaccine modified...
This study was designed to develop and evaluate a chitosan-collagen-soybean phosphatidylcholine (SPC) complex film impregnated with mitomycin C (MMC)-PLA- nanoparticles for treatment of hepatocellular carcinoma in mice. MMC-PLA-nanoparticles were prepared by a reverse micelle-solvent evaporation method. PLA-MMC-nanoparticles were dispersed throughout the film. SEM, ATR-FTIR were used to character...
Pollution made cancer a major disease threatening people's health. In the search for new cancer drug treatments, natural products perform an essential role. Escin, a mixture of triterpene saponins extracted from Aesculus Wilsonii Rehd., was used to analyze the cell growth inhibitory effects and the induction of apoptosis in human cervical carcinoma Hela cancer cell line in vitro. The results of MTT...
This study investigates the impact of focused ultrasound (FOS)-induced blood-brain barrier (BBB) disruption delivery of doxorubicin (DOX) on the survival of rats with aggressive glioma. Results show a modest but significant increase in median survival time in rats treated with combined FUS+DOX, while neither DOX nor FOS has any significant impact on survival on its own. Moreover, a post-treatment...
To make significant progress in the fight against cancer, treatment should target cells more specifically, produce fewer side effects, be easy to administer and deter tumor viability on multiple levels. We have attained dramatic in vivo tumor shrinkage and tumor vasculature disruption using a ternary biomolecular nanoparticle comprised of polymeric carrier polysaccharide heparin, anticancer drug retinoid...
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