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We present here an electric circuit model that fits the behavior of iridium oxide coated electrodes when tested in vitro and in vivo. Our objective is to understand the interface between the active iridium oxide and the biological tissue. In order to do that we have first measured the impedance and the cyclic voltammetry in five electrodes which we later implanted in the hippocampi of rodents. While...
Cortical neural prostheses require chronically implanted small-area microelectrode arrays that simultaneously record and stimulate neural activity. It is necessary to develop new materials with low interface impedance and large charge transfer capacity for this application and we explore the use of conducting polymer poly(3,4-ethylenedioxythiophene) (PEDOT) for the same. We subjected PEDOT coated...
The mechanisms underlying performance degradation of electrodes chronically implanted in the central nervous system (CNS) remain unclear. Several components of the normal brain wound healing response were evaluated to determine if their presence correlates with increased electrical impedance that may be a factor in loss of device performance. Microelectrode recording arrays were electrically characterized...
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