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In this study, the safety with efficacy of infusional 5-fluorouracil (5-FU) (200 mg/m 2 /day) combined with subcutaneous interleukin-2 (IL-2) (9-27 10 6 IU/day) was investigated in patients with metastatic and renal cancer. In the 24 patients evaluated, the overall response rate was 17% (1 CR, 3 PR). The major toxicity was the vascular leak syndrome (VLS) which required inotrope...
The therapeutic effects of fibroblast-mediated human interferon-alpha (IFN-α) gene therapy, alone or in combination with Doxorubicin (Dox), a chemotherapeutic agent, on the human leukemia-bearing nude mice were investigated. An NIH3T3 fibroblast clone (NIH3T3-IFN-α + ) secreting the highest level of human IFN-α + was obtained from the human IFN-α genetransfected fibroblasts. Three...
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