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The therapeutic effects of fibroblast-mediated human interferon-alpha (IFN-α) gene therapy, alone or in combination with Doxorubicin (Dox), a chemotherapeutic agent, on the human leukemia-bearing nude mice were investigated. An NIH3T3 fibroblast clone (NIH3T3-IFN-α + ) secreting the highest level of human IFN-α + was obtained from the human IFN-α genetransfected fibroblasts. Three...