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The purpose of this article was to observe interaction between drug and cancer cell with fluorescence probes and molecular imaging technology. In order to study the effect of cell growth and apoptosis morphology of Human gastric adenocarcinoma SGC-7901 induced by n-butanol extract from Capparis spionosa L. (CSBE), laser scanning microscopy was employed to observe apoptosis imaging. In addition, the...
Propose: Idiopathic orbital inflammatory pseudotumors (IOIP) are inflammatory pseudotumors (IPT) of unknown etiology that develop in the orbit. Due to the lack of well-defined pathogenic mechanisms and diagnostic markers, diagnosis and treatment of this disease remain a significant challenge. Therefore, the aims of this study are to define the etiological factors of IOIP and to identify potential...
DNA polymerase β (pol β) is the base excision repair (BER) polymerase which removes oxidative lesion bases caused by chemotherapeutic agents. Adriamycin (ADM) has been found to kill tumor cells through producing oxidative free radicals, thereby leading to DNA/chromosomal damage as well as gene mutation. Deregulation of the expression of pol β may be important in the predisposition of cell to adriamycin...
Abstract-In this paper we discuss methylation sequencing of DNA target in E-Cadherin gene in head and neck cancer and colorectal cancer by bisulfite-PCR. Bisulfite converted genomic DNA were purified prior to amplification by PCR. Primers are designed to amplify both methylated and unmethylated strands of target DNA sequence. Status of methylation was ascertained by native PAGE. Intriguingly, we have...
In somatic gene therapy, new concepts for the transfer of DNA into specific cell nucler are of interest. In this study, the feasibility of using magnetic nanoparticles with chemotherapeutant (PEI-As2O3/ Mn0.5Zn0.5Fe2O4) as gene vector is evaluated. Mn0.5Zn0.5Fe2O4 magnetic nanoparticles(MZF-NPs), obtained through co-precipitation method, were firstly combined with As2O3 to prepare As2O3/Mn0.5Zn0.5...
Spatial analysis of gene localization using fluorescent in-situ hybridization (FISH) labeling is potentially a new method for early cancer detection. Current methodology relies heavily upon accurate segmentation of cell nuclei and FISH signals in tissue sections. While automatic FISH signal detection is a relatively simpler task, accurate nuclei segmentation is still a manual process which is fairly...
The identification of chromosome abnormalities is an essential part of diagnosis and treatment of genetic disorders such as chromosomal syndromes and many types of cancer. Modern cytogenetic imaging techniques have improved the study of chromosome aberrations but they are most often used as adjuncts to traditional G-banded karyotype analysis. Molecular cytogenetic techniques such as comparative genomic...
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