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Parkinson's disease (PD) is the second most common neurodegenerative condition affecting patients in the UK after Alzheimer's disease. It is broadly classified as a ‘movement disorder’ with a variety of clinical features, including bradykinesia, rigidity and tremor. Traditionally, focus has fallen on the treatment of ‘motor’ complications, such as tremor and mobility problems, although these features...
Parkinson’s disease (PD) is the second most common neurodegenerative condition affecting patients in the UK after Alzheimer’s disease. It is broadly classified as a ‘movement disorder’ with a variety of clinical features, including bradykinesia, rigidity and tremor. Traditional focus has fallen on the treatment of ‘motor’ complications such as tremor and mobility problems although these features are...
Recent evidence indicates that adenosine A2A receptors modulate the activity of striatal neurons, and that antagonists of this receptor may have actions in various animal models related to motor function. Four experiments were conducted to study the effects of systemic injections of the adenosine A2A antagonist KF17837 on the behavioral effects produced by repeated administration of the dopamine (DA)...
Rationale. Although most rodent studies related to parkinsonian symptoms have focused on locomotion, tremulous jaw movements also have been used as a rodent model of tremor for investigating the circuitry of the basal ganglia. Objective. There are multiple pathways involved in the generation of parkinsonian symptoms. The globus pallidus is a basal ganglia relay nucleus, and the present study was conducted...
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