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l-selectin is constitutively expressed on most leukocytes and is responsible for the initial events in cell trafficking termed tethering and rolling. Recently, l-selectin has been shown to associate with the actin-based cytoskeleton under a variety of conditions. In an effort to better understand l-selectin cytoskeletal association and the ultrastructural nature of the cytoskeleton itself, we provide...
Discordant xenografts surviving the initial hyperacute rejection phase may be subject to cellular rejection processes mediated by infiltrating leukocytes including T cells, NK cells and monocytes. The stable adhesion of these cell types to endothelial cells is due to the molecular interaction of the integrins VLA-4 and LFA-1 with their ligands vascular cell adhesion molecule (VCAM) and ICAM-1 present...
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