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A large number of long non-coding RNAs (lncRNAs) have been identified over the past decades. Accumulating evidence proves that lncRNAs play key roles in various biological processes. However, the majority of the lncRNAs have not been functionally characterized. The annotation of lncRNA functions has become an area of focus in the fields of biology and bioinformatics. In this paper, we develop a global...
Surface electromyography (sEMG) signals play a major role in pattern recognition and prosthesis control. In this paper, an efficient scheme is proposed to classify basic hand movements from the sEMG signals based on autocorrelation domain feature extraction. At first a given frame of raw sEMG signal is divided into short duration sub-frames and each frame is subjected to autoregressive (AR) modeling...
Genes that share transcription factors are biologically driven to show a more likely measurable correlation in their gene expression. No modern method of visualization displays these intricate co-expression and correlation patterns better than a graph. Structural observations about a co-expression graph can reveal the secrets of the biological system that it models, but experimentally validated co-expression...
Possible drug side-effects (SEs) are usually verified by many years of repeated clinical trials. Despite the effort, some drugs are still expected to cause adverse reactions in some patients. To better predict drug SEs without having to go through the laborious processes of testing and re-testing, machine learning (ML) techniques are more and more used to uncovered patterns in drug data for such purpose...
Gene (microRNA) identification is a key step in understanding the cellular mechanisms. Compared with biological experiments, computational prediction of disease genes is cheaper and more effortless. In this study, we analyzed the properties of tumor-associated microRNA in mouse and found that tumor-associated genes display 8distinguishingfeatures when compared with genes not yet known to be involved...
Recent advances in sequencing allow the study of all identified human genes (≈ 22,000 protein encoding genes), which have differential expression between tissues. However, current knowledge on gene interactions lags behind, especially when one of the elements encodes a mitochondrial protein (≈ 1500). Mitochondrial proteins are encoded either by mitochondrial DNA (mtDNA; 13 proteins) or by nuclear...
With the development of next-generation sequencing technologies, large number of transcripts has been accumulated in public databases. Long non-coding RNAs (lncRNAs), typically above 200 nucleotides in sequence length, have recently attracted increasing interests because of their important roles in various cellular processes. While it is straightforward to distinguishing lncRNAs from most small non-coding...
In this paper authors have studied the current state of the art, noting the achievements and gaps existing in published works. Most of the gaps are related to the testing data used, and therefore the reliability of the results obtained. With this in mind, the paper not only covers such review of the literature, but also the efforts of the authors in developing a solution that could demonstrate the...
The main purpose of this paper is to develop a system for the early diagnosis and detection of abnormalities of any patient during gait cycle. A malfunction in the gait cycle leads to pain, and undesirable effects on the bones of the legs due to large forces exerted on specific areas. The gait cycle is divided into two main phases, the stance that is characterized as the contact of the right leg with...
In this paper, a description of the software is provided that allows to obtain an automated objective quantitative assessment of the patient's speech quality. The evaluation is carried out in the process of speech rehabilitation after surgical treatment of oncological diseases of the organs of the speech-forming tract. The evaluation is obtained based on comparing patient records before the operation...
Overhead distribution lines are usually subject to voltage transients during thunderstorms. Lightning flashes, whether direct or indirect, are one of the main causes of power quality disturbances on the electric grid. In this paper, a methodology to establish a correlation between the incidence point of a lightning flash, the stroke current amplitude and polarity and its effects on the electric distribution...
This paper discusses the motivation and implementation for Cray's Project Caribou. Project Caribou enables users to correlate HPC job performance with Lustre file systems through collected metrics and events. We will discuss use cases, the sources of metrics that are collected, correlation, and how the data is visualized. Additional topics to include events and alerts that are available, as well as...
This paper describes three methods for multiple fundamental frequencies estimation based on the multi-scale product analysis. The three methods use the autocorrelation of the multi-scale product analysis for the target pitch estimation. For the intrusion pitch, each one has its techniques. The first one uses the classic comb filtering. The second method employs the rectangular comb filter followed...
This paper presents the current problematic of development a set of indicators user direction, informational direction and reputational direction to perform task of directions of the organization of life cycle of virtual community. The method of determination of possible variants of balancing indicators of virtual community is developed. These indicators based on the analysis of the subject area of...
Organizations face the issue of how to best allocate their security resources. Thus, they need an accurate method for assessing how many new vulnerabilities will be reported for the operating systems (OSs) they use in a given time period. Our approach consists of clustering vulnerabilities by leveraging the text information within vulnerability records, and then simulating the mean value function...
Command extraction from human beings becomes easier for a machine if it can analyze the non verbal ways of communication such as emotions. This paper focuses on improving the efficiency of extracting emotion from human facial expression images. The features that were extracted in this experiment were obtained from JAFFE (Japanese Female Facial Expression) database which includes 213 images of different...
Grey Level Co-Occurrence matrix is one of the oldest techniques used for texture analysis. The Grey Level Co-Occurrence matrix has two important parameters i.e. distance and direction. In this paper various combinations of distance and directional angles used for GLCM calculation are analyzed in order to recognize certain patterned images based on their textural features. Patterns considered in this...
Acoustic parameters are very useful in voice screening, diagnosis and rehabilitation, and also in forensic voice comparison tasks. In this paper we present results for the acoustic analysis performed by two different voice analysis platforms and involving five sustained vowels uttered by 10 female speakers and 9 male speakers. We consider contemporaneous high-quality (HQ) and GSM voice recordings,...
Tracheoesophageal (TE) speech is generated by patients who have undergone a total laryngectomy where the larynx (voice box) is removed and replaced by a tracheoesophageal puncture. This work presents a novel low complexity algorithm to estimate the degree of severity of disordered TE speech. The proposed algorithm uses features which are computed from 32-ms voiced frames of the speech signal. A 21-st...
Epilepsy is a typical neurological disorder. To find the characteristics of epilepsy, scalp level connectivity is one of the interests that widely studied before. However, another aspect about the scalp representative channels, which presents the synchronous regions, has not yet been investigated. In this work, we focus on study the scalp responses of epilepsy by connectivity and representative channels...
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