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Items from 1 to 12 out of 12 results

article

Retrospective observational study of changes in serum cytokines and adiponectin with continuous plasma exchange with dialysis therapy for severe COVID‐19

Yuya Suzuki, Hajime Nakae, Kasumi Satoh, Nobuhisa Hirasawa, more

Therapeutic Apheresis and Dialysis > 27 > 6 > 1028 - 1034

Introduction Coronavirus disease 2019 (COVID‐19) is associated with a marked increase in the inflammatory cytokines, IL‐6 and IL‐18. Blood purification therapy aimed at controlling cytokines is one treatment option; however, evidence of its effectiveness is needed. Plasma exchange with dialysis (PED) is a blood purification method involving selective plasma exchange with dialysate flowing through...

article

The landscape of differential splicing and transcript alternations in severe COVID‐19 infection

Sunanda Biswas Mukherjee, Sumit Mukherjee, Rajesh Detroja, Milana Frenkel‐Morgenstern

The FEBS Journal > 290 > 12 > 3128 - 3144

Viral infections can modulate the widespread alternations of cellular splicing, favouring viral replication within the host cells by overcoming host immune responses. However, how SARS‐CoV‐2 induces host cell differential splicing and affects the landscape of transcript alternation in severe COVID‐19 infection remains elusive. Understanding the differential splicing and transcript alternations in...

article

Clinical characteristics of COVID‐19 in solid organ transplant recipients following COVID‐19 vaccination: A multicenter case series

Kapil K. Saharia, Shweta Anjan, Judy Streit, Susan E. Beekmann, more

Transplant Infectious Disease > 24 > 2 > n/a - n/a

Background Solid organ transplant recipients (SOTR) have diminished humoral immune responses to COVID‐19 vaccination and higher rates of COVID‐19 vaccine breakthrough infection than the general population. Little is known about COVID‐19 disease severity in SOTR with COVID‐19 vaccine breakthrough infections. Methods Between 4/7/21 and 6/21/21, we requested case reports via the Emerging Infections...

article

Efficacy and safety of current treatment interventions for patients with severe COVID‐19 infection: A network meta‐analysis of randomized controlled trials

Qinglin Cheng, Gang Zhao, Junfang Chen, Qingjun Jia, more

Journal of Medical Virology > 94 > 4 > 1617 - 1626

This study aimed to assess the efficacy and safety of different medications available at present for severe coronavirus disease 2019 (COVID‐19) infection. We searched databases for randomized controlled trials (RCTs) published up to April 30, 2021, with Chinese or English language restriction, of medications recommended for patients (aged 18 years or older) with severe COVID‐19 infection. We extracted...

article

Hypersensitivity may be involved in severe COVID‐19

Cuiyan Tan, Xiaobin Zheng, Fengfei Sun, Jianzhong He, more

Clinical & Experimental Allergy > 52 > 2 > 324 - 333

Background Deaths attributed to Coronavirus Disease 2019 (COVID‐19) are mainly due to severe hypoxemic respiratory failure. Although the inflammatory storm has been considered the main pathogenesis of severe COVID‐19, hypersensitivity may be another important mechanism involved in severe cases, which have a perfect response to corticosteroids (CS). Method We detected the serum level of anti‐SARS‐CoV‐2–spike...

article

Chronic dysglycemia and risk of SARS‐CoV‐2 associated respiratory failure in hospitalized patients

Susanne Rysz, Malin Jonsson Fagerlund, Claire Rimes‐Stigare, Emma Larsson, more

Acta Anaesthesiologica Scandinavica > 66 > 1 > 48 - 55

Background Diabetes is common among patients with severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2)‐induced respiratory failure. We aimed to investigate the relationship between different stages of chronic dysglycemia and development of respiratory failure in hospitalized SARS‐CoV‐2 positive patients. Methods In this retrospective observational study, we included 385 hospitalized SARS‐CoV‐2...

article

Laboratory parameters related to severe disease and death in SARS‐CoV‐2 pneumonia: Retrospective analysis

Giovanna Picchi, Monica Di Norcia, Vincenza Cofini, Gaia Sinatti, more

Journal of Medical Virology > 93 > 10 > 5886 - 5895

The clinical evolution of coronavirus disease 2019 (COVID‐19) is highly variable and hospitalized patients can rapidly develop conditions requiring oxygen support, intensive care unit (ICU) or high dependency unit (HDU) care. Early identification of high‐risk patients is mandatory. We retrospectively collected the medical history, symptoms, radiological, and laboratory findings of COVID‐19 patients...

article

Janus kinase signaling as risk factor and therapeutic target for severe SARS‐CoV‐2 infection

Farzan Solimani, Katharina Meier, Kamran Ghoreschi

European Journal of Immunology > 51 > 5 > 1071 - 1075

Cytokine signaling, especially interferon (IFN) signaling is closely linked to several aspects of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection. During initial SARS‐CoV‐2 infection, symptomatic patients present with impaired type I/III IFN‐mediated antiviral responses. Interestingly, IFNs regulate the cellular entry receptor for SARS‐CoV‐2 on epithelial and endothelial cells...

article

Successfully treated severe COVID‐19 and invasive aspergillosis in early hematopoietic cell transplantation setting

Manuela Spadea, Francesca Carraro, Francesco Saglio, Elena Vassallo, more

Transplant Infectious Disease > 23 > 2 > n/a - n/a

article

Diabetes predicts severity of COVID‐19 infection in a retrospective cohort: A mediatory role of the inflammatory biomarker C‐reactive protein

Huilin Koh, Angela Mei Chung Moh, Ester Yeoh, Yi Lin, more

Journal of Medical Virology > 93 > 5 > 3023 - 3032

Diabetes is a risk factor for developing severe COVID‐19, but the pathogenesis remains unclear. We investigated if the association of diabetes and COVID‐19 severity may be mediated by inflammation. We also hypothesized that this increased risk may extend to prediabetes. Hospitalized patients in Singapore with COVID‐19 were subdivided into three groups in a retrospective cohort: normoglycemia (HbA1c:...

article

Dermatologic comorbidities of the patients with severe COVID‐19: A case‐control study

Ömer Kutlu, Neslihan Demirel Öğüt, Ece Erbağcı, Ahmet Metin

Dermatologic Therapy > 34 > 1 > n/a - n/a

The current studies focus on the association between COVID‐19 and certain comorbidities. To the best of our knowledge, the association between severe COVID‐19 and dermatologic comorbidities has not been reported yet. In this study, we aimed to describe the dermatologic comorbidities of patients with severe COVID‐19 and compare it with the control group. Patients who have died at Uşak Training and...

article

COVID‐19‐associated pulmonary aspergillosis (CAPA) in patients admitted with severe COVID‐19 pneumonia: An observational study from Pakistan

Nosheen Nasir, Joveria Farooqi, Syed Faisal Mahmood, Kauser Jabeen

Mycoses > 63 > 8 > 766 - 770

Background Invasive aspergillosis is a well‐known complication of severe influenza pneumonia with acute respiratory distress syndrome (ARDS). However, recent studies are reporting emergence of aspergillosis in severe COVID‐19 pneumonia, named as COVID‐19‐associated pulmonary aspergillosis (CAPA). Methods A retrospective observational study was conducted in patients with severe COVID‐19 pneumonia...

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SEVERE COVID‐19 (12)
RESPIRATORY FAILURE (2)
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