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Items from 1 to 20 out of 387 results

article

A novel scoring system to predict survival in cirrhotic patients undergoing isolated lung transplantation: The PENS‐CEPT score

Eric J. Hyzny, Ernest G. Chan, Chadi Hage, Vikrant Rachakonda, more

Clinical Transplantation > 37 > 10 > n/a - n/a

Cirrhosis is usually regarded as a contraindication to isolated lung transplantation (ILT). We sought to determine which patients with cirrhosis could safely undergo ILT. Based on a retrospective analysis of patients with cirrhosis who underwent ILT at our center between 2007 and 2020, we developed an exclusionary algorithm (PENS‐CEPT: Pittsburgh ExclusioN Score in Cirrhotics Evaluated for Pulmonary...

article

Determining Predictors of Actual Living Kidney Donation Based on Potential Donor Characteristics

Andrea M. Meinders, Edward A. Graviss, Duc T. Nguyen, Jonathan Daw, more

Clinical Transplantation > 38 > 9 > n/a - n/a

Background Living donor kidney transplantation is the optimal treatment for end‐stage kidney disease; however, few living donor candidates (LDCs) who begin evaluation actually donate. While some LDCs are deemed medically ineligible, others discontinue for potentially modifiable reasons. Methods At five transplant centers, we conducted a prospective cohort study measuring LDCs’ clinical and psychosocial...

article

Treatment Strategies for Bile Leak Following Pediatric Liver Transplantation

João Seda Neto, Carolina M. Costa, André M. de Assis, Renata Pugliese, more

Pediatric Transplantation > 28 > 5 > n/a - n/a

There are no standard management protocols for the treatment of bile leak (BL) after liver transplantation. The objective of this study is to describe treatment options for BL after pediatric LT. Methods Retrospective analysis (January 2010–March 2023). Variables studied: preoperative data, status at diagnosis, and postoperative outcome. Four groups: observation (n = 9), percutaneous transhepatic...

article

Strategies for choosing the best living donor: A review of the literature and a proposal of a decision‐making paradigm

Olga Charnaya, Kyle Van Arendonk, Dorry L. Segev

Pediatric Transplantation > 28 > 4 > n/a - n/a

Transplantation remains the gold‐standard treatment for pediatric end‐stage kidney disease. While living donor transplant is the preferred option for most pediatric patients, it is not the right choice for all. For those who have the option to choose between deceased donor and living donor transplantation, or from among multiple potential living donors, the transplant clinician must weigh multiple...

article

Cost‐effectiveness analysis of adult living‐donor liver transplantation in Japan

Tetsuya Tajima, Jung‐Ho Shin, Susumu Kunisawa, Noriko Sasaki, more

Hepatology Research > 54 > 5 > 465 - 478

Aim Living‐donor liver transplantation (LDLT) is a highly effective life‐saving procedure; however, it requires substantial medical resources, and the cost‐effectiveness of LDLT versus conservative management (CM) for adult patients with end‐stage liver disease (ESLD) remains unclear in Japan. Methods We performed a cost‐effectiveness analysis using the Diagnostic Procedure Combination (DPC) data...

article

Clinical performance of the iPREDICTLIVING tool for the prediction of the post‐transplant recipient and living donor outcomes in a European cohort

Manuela Almeida, Catarina Ribeiro, José Silvano, Sofia Pedroso, more

Clinical Transplantation > 38 > 3 > n/a - n/a

A living donor kidney transplant (LDKT) is the best treatment for ESRD. A prediction tool based on clinical and demographic data available pre‐KT was developed in a Norwegian cohort with three different models to predict graft loss, recipient death, and donor candidate's risk of death, the iPREDICTLIVING tool. No external validations are yet available. We sought to evaluate its predictive performance...

article

Evaluation of rapid optimized flow cytometry crossmatch (Halifaster) in living donor kidney transplantation

Luis Ramalhete, Rúben Araújo, Cristiana Teixeira, Ana Teixeira, more

HLA > 103 > 2 > n/a - n/a

Kidney transplantation is often the preferred treatment for end‐stage renal disease. However, the presence of preformed donor‐specific antibodies (DSA), including those against HLA, can lead to antibody‐mediated rejection and significantly impact transplant outcomes. The Flow Cytometry Crossmatch (FCXM) is a crucial tool in kidney transplantation, as it also enables the measurement of low levels of...

article

The impact of high volumes of COVID‐related lung transplant on waitlist mortality for non‐COVID candidates in the United States

Maxwell Marshall, Joshua Diamond, Hilary Goldberg, Andrew Courtwright

Clinical Transplantation > 38 > 2 > n/a - n/a

Some patients with coronavirus disease 19 (COVID) develop serious, irreversible lung disease, including acute respiratory distress syndrome or pulmonary fibrosis. For select candidates, lung transplant is the only option to improve quality and length of life. Because of the severity of end‐stage COVID‐related lung disease, these candidates receive high allocation priority in the United States, including...

article

Performance of estimated glomerular filtration rate equations in Black living kidney donor candidates

Joshua J. Augustine, Aimen Liaqat, Susana Arrigain, Jesse D. Schold, more

Clinical Transplantation > 38 > 1 > n/a - n/a

Introduction New estimated glomerular filtration rate (eGFR) equations using serum creatinine and/or cystatin C have been derived to eliminate adjustment by perceived Black ancestry. We sought to analyze the performance of newer eGFR equations among Black living kidney donor candidates. Methods Black candidates (n = 64) who had measured iothalamate GFR between January 2015 and October 2021 were...

article

Combined liver‐kidney transplantation in pediatric patients

Nam‐Joon Yi, Jiyoung Kim, Su Young Hong, Hee Gyung Kang

Pediatric Transplantation > 28 > 1 > n/a - n/a

Combined liver‐kidney transplantation (CLKT) is a surgical procedure that involves transplanting both liver and kidney organs. There are two types of CLKT: simultaneous liver‐kidney transplantation (smLKT) and sequential LKT (sqLKT). CLKT accounts for a small percentage of liver transplantations (LTs), particularly in pediatric cases. Nevertheless, the procedure has demonstrated excellent outcomes,...

article

Recanalization of portal vein thrombosis after pediatric liver transplantation: Efficacy and safety of the transsplenic access

Aline Cristine Barbosa Santos Cavalcante, Francisco César Carnevale, Charles Edouard Zurstrassen, Renata Pereira Sustovich Pugliese, more

Pediatric Transplantation > 28 > 1 > n/a - n/a

Background Endovascular management of portal vein thrombosis (PVT) is challenging. Transsplenic access (TSA) is growing as an access option to the portal system but with higher rates of bleeding complications. The aim of this article is to evaluate the efficacy and safety of transsplenic portal vein recanalization (PVR) using a metallic stent after pediatric liver transplantation. Materials and...

article

Safety and utility of panniculectomy in renal transplant candidates and end stage renal disease patients

Matteo Laspro, Thor S. Stead, Brooke Barrow, Hilliard T. Brydges, more

Clinical Transplantation > 38 > 1 > n/a - n/a

Background As the obesity crisis in the United States continues, some renal transplantation centers have liberalized their BMI criteria necessary for transplant eligibility. More individuals with larger body‐habitus related comorbidities with End‐Stage Renal Disease (ESRD) now qualify for renal transplantation (RT). Surgical modalities from other fields also interact with this patient population...

article

Laparoscopic to robotic living donor nephrectomy: Is it time to change surgical technique?

Sarah Papa, Aleksandar Popovic, Sharon Loerzel, Samir Iskhagi, more

The International Journal of Medical Robotics and Computer Assisted Surgery > 19 > 6 > n/a - n/a

Background We aimed to explore differences in outcomes of robotic and laparoscopic donor nephrectomies (LDN). Methods This study compared robotic and laparoscopic surgical techniques for live donor nephrectomies in 153 patients at a single centre. Results Left nephrectomies were more common in both groups, but with no significant difference between the groups (76.6% vs. 77.6%, p = 0.88). The...

article

Donor safety of remnant liver volumes of less than 30% in living donor liver transplantation: A systematic review and meta‐analysis

Sang‐Hoon Kim, Ki‐Hun Kim, Hwui‐Dong Cho

Clinical Transplantation > 37 > 9 > n/a - n/a

Purpose This meta‐analysis aimed to investigate the acceptability of donor remnant liver volume (RLV) to total liver volume (TLV) ratio (RLV/TLV) being <30% as safe in living donor liver transplantations (LDLTs). Methods Online databases were searched from January 2000 to June 2022. Pooled odds ratios (ORs) and standardized mean differences (SMDs) with 95% confidence intervals (CIs) were calculated...

article

Living well or not? Quality of life of parental living liver donors: A cross‐sectional study

Xiaxin Wu, Jing Chen, Yaru Fan, Yuexian Shi, more

Journal of Clinical Nursing > 32 > 15-16 > 5113 - 5125

Aim The aim of this study was to gain comprehensive insight into the quality of life of parental living liver donors after liver donation. Background Several studies reported good quality of life of living liver donors with the SF‐36 scale. Care demand from the recipient and responsibility of being parent might make a difference in parental donors' personal experienced quality of life after transplantation...

article

A systematic review of opioid use and multimodal strategies in solid organ transplant recipients and living donors

Heather L. Kutzler, Alicia B. Lichvar, David Quan, Lyndsey J. Bowman, more

Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy > 43 > 6 > 514 - 551

The opioid epidemic has impacted analgesia in the postoperative period for solid organ transplant (SOT) donors and recipients. However, optimal pain management and opioid stewardship strategies have not been identified across this unique population. The purpose of this systematic review was to evaluate the impact of perioperative opioid use and to describe multimodal analgesic strategies to reduce...

article

Vulnerability, Autonomy, and the Living Organ Donor

Christy Simpson

Hastings Center Report > 53 > 1 > 46 - 47

The Living Organ Donor as Patient: Theory and Practice, by Lainie Friedman Ross and J. Richard Thistlethwaite, Jr. (Oxford University Press, 2021), offers a stimulating opportunity to consider the ethics of living solid organ donation in more depth. Ross and Thistlethwaite detail a framework of five principles—respect for persons, beneficence, justice, vulnerability, and responsibility—that positions prospective living donors as patients. The authors engage readers by applying these principles across a series of examples, issues, and possibilities, the “practice.” Readers may wish to reflect further on the framework's implications, including those related to vulnerability, power, and social justice (to name a few), particularly as these relate to the “theory” of this book. The book is well worth the read for clinicians, ethicists, and others involved in organ donation and transplantation...

article

Can non‐directed living liver donation help improve access to grafts and correct socioeconomic disparities in pediatric liver transplantation?

Dor Yoeli, Amy G. Feldman, Rashikh A. Choudhury, Hunter B. Moore, more

Pediatric Transplantation > 27 > 2 > n/a - n/a

Background Each year, children die awaiting LT as the demand for grafts exceeds the available supply. Candidates with public health insurance are significantly less likely to undergo both deceased donor LT and D‐LLD LT. ND‐LLD is another option to gain access to a graft. The aim of this study was to evaluate if recipient insurance type is associated with likelihood of D‐LLD versus ND‐LLD LT. Methods...

article

Delayed graft function in pediatric living donor kidney transplantation

Christine S. Hwang, Yash Kadakia, Jorge A. Sanchez‐Vivaldi, Madhukar S. Patel, more

Pediatric Transplantation > 27 > 2 > n/a - n/a

Background Pediatric recipients of living donor kidneys have a low rate of delayed graft function (DGF). We examined the incidence, risk factors and outcomes of DGF in pediatric patients who received a living donor allograft. Methods The STARfile was queried to examine all pediatric patients transplanted with a living donor kidney between 2000 and 2020. Donor and recipient demographic data were...

article

Optimal surgical workup to ensure safe recovery of the donor after living liver donation – A systematic review of the literature and expert panel recommendations

Giuliano Testa, Silvio Nadalin, Tarunjeet Klair, Sander Florman, more

Clinical Transplantation > 36 > 10 > n/a - n/a

Background The essential premise of living donor liver transplantation is the assurance that the donors will have a complication‐free perioperative course and a prompt recovery. Selection of appropriate donors is the first step to support this premise and is based on tests that constitute the donor workup. The exclusion of liver pathologies and assessment of liver anatomy and volume in the donor...

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A novel scoring system to predict survival in cirrhotic patients undergoing isolated lung transplantation: The PENS‐CEPT score

Determining Predictors of Actual Living Kidney Donation Based on Potential Donor Characteristics

Treatment Strategies for Bile Leak Following Pediatric Liver Transplantation

Strategies for choosing the best living donor: A review of the literature and a proposal of a decision‐making paradigm

Cost‐effectiveness analysis of adult living‐donor liver transplantation in Japan

Clinical performance of the iPREDICTLIVING tool for the prediction of the post‐transplant recipient and living donor outcomes in a European cohort

Evaluation of rapid optimized flow cytometry crossmatch (Halifaster) in living donor kidney transplantation

The impact of high volumes of COVID‐related lung transplant on waitlist mortality for non‐COVID candidates in the United States

Performance of estimated glomerular filtration rate equations in Black living kidney donor candidates

Combined liver‐kidney transplantation in pediatric patients

Recanalization of portal vein thrombosis after pediatric liver transplantation: Efficacy and safety of the transsplenic access

Safety and utility of panniculectomy in renal transplant candidates and end stage renal disease patients

Laparoscopic to robotic living donor nephrectomy: Is it time to change surgical technique?

Donor safety of remnant liver volumes of less than 30% in living donor liver transplantation: A systematic review and meta‐analysis

Living well or not? Quality of life of parental living liver donors: A cross‐sectional study

A systematic review of opioid use and multimodal strategies in solid organ transplant recipients and living donors

Vulnerability, Autonomy, and the Living Organ Donor

Can non‐directed living liver donation help improve access to grafts and correct socioeconomic disparities in pediatric liver transplantation?

Delayed graft function in pediatric living donor kidney transplantation

Optimal surgical workup to ensure safe recovery of the donor after living liver donation – A systematic review of the literature and expert panel recommendations

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