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Glaucoma is a group of disease characterized by progressive optic nerve degeneration and retinal ganglion cells (RGCs). The RGCs and evaluation elevated intraocular pressure are the most common cause for glaucoma. In this study, RGC death pathway of glaucoma was modeled to predict the response of the protein receptor, ligand, inhibitor and other regulatory units, which are involved in RGC death pathway...
Systems biology models and simulation tools are critical components for bridging molecular biology with predictive medicine. We report a systematic comparison of popular simulation tools, including CellDesigner, COPASI and VirtualCell, to facilitate translational research in genomics, proteomics and systems biology. Different tools evaluating the same model may produce dissimilar results. This inconsistency...
Understanding of logic and dynamics of gene-regulatory and biochemical networks is a major challenge of systems biology. To facilitate this research topic, we have developed CellDesigner, a modeling tool of gene-regulatory and biochemical networks. CellDesigner supports users to easily create such networks using solidly defined and comprehensive graphical representation (SBGN: systems biology graphical...
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