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Systems biology models and simulation tools are critical components for bridging molecular biology with predictive medicine. We report a systematic comparison of popular simulation tools, including CellDesigner, COPASI and VirtualCell, to facilitate translational research in genomics, proteomics and systems biology. Different tools evaluating the same model may produce dissimilar results. This inconsistency...
Studies have implicated ceramide as a key molecular agent in regulating programmed cell death, or apoptosis. Consequently, there is significant potential in targeting intracellular ceramide as a cancer therapeutic agent. The cell's major ceramide source is the ceramide de novo synthesis pathway, which consists of a complex network of interdependent enzyme-catalyzed biochemical reactions. To understand...
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