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The EGF receptor is an important target of cancer immunotherapies. The 7A7 monoclonal antibody has been raised against the murine EGFR, but it cross-reacts with the human receptor. The results from experiments using immune-competent mice can therefore, in principle, be extrapolated to the corresponding scenario in humans. In this work we report the crystal structure of the 7A7 Fab at an effective...
It is well established that the “switch” from an avascular to the vasculogenic phenotype is required for growth as well as metastasis of the tumor. Multiple regulators of angiogenesis, positive and negative, have been described. Due to the tumor growth dependence on angiogenesis, anti-angiogenic therapy is rapidly evolving as anticancer strategy. Antibodies and inhibitors directed against pro-angiogenic...
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