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How dendritic cells (DCs) gather information from the local milieu at a site of infection or injury and communicate this to influence adaptive immunity is not well understood. We and others have reported that soon after microbial encounter, DCs secrete the p40 subunit of IL-12, by itself, in a monomeric form. Based on recent data that this p40 monomer subsequently associates with p35 released from...
The immune system neither discriminates between ‘Self’ and Nonself’, nor it acts when confronting ‘Danger’, rather, it reacts to disruption of tissue integrity allowing its renewal. The ‘integrity’ hypothesis proposes three groups of signals that coordinate actions of dendritic cells and immunocytes during the initiation of the specfic immune response, and suggests explanations for tolerance, memory...
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