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Thymosin β4 (Tβ4) has been shown to have beneficial effects in a number of pathological processes. Although there was research reporting the endogenous expression of Tβ4 influences hepatic stellate cells (HSCs) activation, the effect of exogenous administration of Tβ4 in hepatic fibrosis remains unclear. In the current study, we used CCl4-induced liver fibrosis model mice to investigate the effect...
We use analogies between chemistry and subthreshold electronics to develop fast, scalable, digitally programmable hardware models of stochastic genetic networks. We also present experimental results from a prototype 0.18 ??m CMOS chip that was designed for rapid simulations of gene activation, transcription and translation.
The regulation of gene transcription in eukaryotes, though not well understood, is known to involve sequence specific recognition and binding of short DNA sequences (transcription elements) by regulatory proteins (transcription factors). The cis acting transcription elements can be found at a considerable distance upstream or downstream from the gene they control and are often orientation independent...
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