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A Mach-Zehnder refractive index sensor is inscribed in a microfluidic lab-on-a-chip by exploiting the unique three-dimensional capabilities of femtosecond laser fabrication. This enables high sensitivity and spatially resolved label-free detection of biomolecules.
In this research, we present a chip based capillary electrochromatography (CEC) carrying out a highly efficient separation of biomolecules through gradient hydrophobic stationary phase (GHSP) provided by multiwalled carbon nanotubes (MWCNTs) nanocolumns. 4-azidoaniline was employed for the surface modification of the MWCNTs to form a gradient stationary phase by a photochemical reaction through a...
In the future, devices based on lab-on-a-chip, compact and inexpensive detection units are required that directly translate the abundance of certain biomolecules into an electronic signal. By detecting specifically bound magnetic labels with magnetoresistive sensors, a versatile platform can be designed that fulfils those requirements and even enables on-chip manipulation of biomolecules by suitable...
Electrochemical impedance detection of biomolecules relies on the electrode system used. The architecture of the metal electrodes, on top of which the biosensing materials and consequently the target molecules are immobilized, is of particular importance. A high and uniform sensitivity of the sensor to impedance changes in regions of interest is required. In this paper, the sensitivity of tetrapolar...
The coupling of semiconductor field-effect devices (FEDs) together with chemical and biological recognition elements, like functional intelligent materials, biomolecules and living cells, represents an attractive platform for creating various bio- and chemical sensors, multi-parameter analysis systems and biochips. This paper is focussing on recent developments and current research activities in the...
In this paper we present a lab-on-glass system for label free DNA analysis that integrates a polymerase chain reaction (PCR) chamber for DNA amplification, an electrowetting-based droplet-handling system and a hydrogenated amorphous silicon ultraviolet sensor array for DNA detection. The photosensors allow to measure the absorbance of the biomolecules at 254 nm to reveal and quantify the DNA sample...
A low-cost, flexible, and disposable immunosensor is presented in this paper. The single-walled carbon nanotubes (SWNT) and biomolecules are self-assembled on micro patterned electrodes. The immuno-chip acts as the platform of a horseradish peroxidase (HRP) labeled sandwiched Enzyme-Linked Immunosorbent Assay (ELISA). The pH change induced by the biochemical reactions influences the electrical conductance...
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