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We present a MEMS-based differential scanning calorimetric (DSC) device combining highly sensitive thermoelectric sensing, on-chip self-calibration, and microfluidic regulation for thermodynamic characterization of biomolecular samples on a minimized scale. The device integrates well-defined microfluidic reaction chambers and utilizes a three-dimensional structure in which a layer of resistive microheaters...
We have developed a highly-sensitive leakage current microsensor by using 1,2-dipalmitoyl-sn-glycero-3 phosphocholline (DPPC) liposome entrapping K4[Fe(CN)6] solution to detect existence of biomolecules especially proteins and their dynamic conditions. In this work, the addition of guanidinium hydrochloride (GuHCl) as protein denaturant successfully leads a prominent improvement in sensitivity by...
We present a unique microfluidic platform to allow for quick and sensitive probing of protein adsorption to various functionalized surfaces. The ability to tailor a sensor surface for a specific analyte is crucial for the successful application of portable gas and fluid sensors and is of great interest to the drug screening community. However, choosing the correct surface chemistry to either block...
This paper discusses the design of a CMOS-MEMS diffraction grating for a micro spectrophotometer with application in non-invasive glucose monitoring based on differential near-infrared spectro photometry. There are typically two factors discussed with respect to diffraction gratings: spectral range and optical resolution. An analysis of the tradeoff between these two parameters was performed for the...
In this paper we have proposed and analyzed a novel integrated optic racetrack resonator based biosensor. The device is capable of distinguishing compressive and tensile stresses on a cantilever due to conformational changes of protein. We have considered Bovine Serum Albumin (BSA) and Immunoglobulin G (IgG). The change of surface stress upon adsorption of IgG is compressive and of BSA is tensile...
Gold - poly(dimethylsiloxane) (Au - PDMS) nanocomposite freestanding films were prepared and used to study the binding of Human Serum Albumin (HSA) to polyclonal anti-HSA. A new method of synthesis was developed for sensing application when most of the gold nanoparticles have to be localized in the surface layer. The localized surface plasmon resonance band in gold nanoparticles is used to monitor...
Natural materials exhibit anisotropy with variations in soluble factors, cell distribution, and matrix properties. The ability to recreate the heterogeneity of the natural materials is a major challenge for investigating cell-material interactions and for developing biomimetic materials. Here we present a generic fluidic approach using convection and alternating flow to rapidly generate multi-centimeter...
In this research, we present a chip based capillary electrochromatography (CEC) carrying out a highly efficient separation of biomolecules through gradient hydrophobic stationary phase (GHSP) provided by multiwalled carbon nanotubes (MWCNTs) nanocolumns. 4-azidoaniline was employed for the surface modification of the MWCNTs to form a gradient stationary phase by a photochemical reaction through a...
In the future, devices based on lab-on-a-chip, compact and inexpensive detection units are required that directly translate the abundance of certain biomolecules into an electronic signal. By detecting specifically bound magnetic labels with magnetoresistive sensors, a versatile platform can be designed that fulfils those requirements and even enables on-chip manipulation of biomolecules by suitable...
This presentation reviews the basic principles of femtosecond laser waveguide writing, as well as its application to the fields of optical communications and biophotonics. Optical waveguides mode-matched to standard single-mode fibers can be used for a variety of telecom devices such as splitters, couplers and interferometers, as well as for active devices, such as erbium-doped waveguide amplifiers...
Molecular biophysicists seek to understand how biological systems work through mechanical or electrical characterizations performed at the molecular scale. From this perspective, we have devised a silicon-based micromechanical tool for stress-strain measurements of molecular fibers and demonstrated micro manipulation and biomechanical characterization of DNA bundles in a liquid solution. By combining...
In this paper we present a lab-on-glass system for label free DNA analysis that integrates a polymerase chain reaction (PCR) chamber for DNA amplification, an electrowetting-based droplet-handling system and a hydrogenated amorphous silicon ultraviolet sensor array for DNA detection. The photosensors allow to measure the absorbance of the biomolecules at 254 nm to reveal and quantify the DNA sample...
Label-free electronic detection of biomolecules has long been a cherished dream for researchers involved in Genomics and Proteomics. Despite significant interest and almost monthly reports of groundbreaking experimental results in leading journals by researchers all over the world, the elements that dictate response of a biosensor has remained - until recently - poorly understood. In this paper, we...
We theoretically and experimentally demonstrate a compact silicon photonic crystal microcavity sensor capable of detecting in vivo a single particle of size comparable to a virus.
Conducting polymer can modify device surface properties and incorporate biomolecules for immobilization by electropolymerization at the same time. We investigated a method for surface modification by electrochemically deposited polypyrrole onto surface of bio-MEMS micro device. We reported the effects of the numbers of CV cycle on the deposited film thickness and roughness in this paper. Furthermore,...
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