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Biomolecular DNA, as a marine waste product from salmon processing, has been exploited as biodegradable polymeric material for photonics and electronics. For preparing high optical quality thin films of DNA, a method using DNA with cationic surfactants such as DNA–cetyltrimethylammonium, CTMA has been applied. This process enhances solubility and processing for thin film fabrication. These DNA–CTMA...
SPA (Speaking Plant Approach) is a comparatively modern cultivation method which grows plant according to their biological information. The SPA plant factory system has suitable elements for use in engineering education. In this paper, a new education trial in KTC (Kanazawa Technical College, a private technical college in Japan) through graduate study of the SPA plant factory system construction...
Bacteriorhodopsin is considered an important biomolecule for biochemical and technology-oriented studies. The modeling and functionality of bacteriorhodopsin sensors have been extensively studied, but the studies lack the analysis of the errors present in the measurements. Further, the impacts of these errors on photoelectric measurements are mostly unknown. In this paper, we discuss the errors caused...
The photoelectric response of dry bacteriorhodopsin sensors varies depending on whether the incident light is on or off. To model this behavior, we have proposed an electrical equivalent circuit that has a capacitor that varies with the light intensity. In this paper, the proposed model is experimentally validated and found to be appropriate even when the light intensity is changed. The results also...
Label-free and rapid analysis of a large-scale cells is essential for single-cell analysis and the point-of-care testing (POCT). We demonstrated a microchip-based impedance flow cytometer for cell identification and counting in single-cell level without labelling. Cells were focused to sequentially flow through a straight channel in a disposable chip. One pair of coplanar sensing electrodes underneath...
Pulsed electric fields of nanosecond duration and high intensity (in the megavolt-per-meter range) have the ability to trigger functional modifications in biological cells, without irreversible disruption of the cell membranes. Although the biophysical mechanisms underlying the induced biological effects are not yet clear, promising applications have been found in biology, medicine and environment...
Electrotaxis is the cell migration induced by the presence of an external electric field (EF). It has been found that electrotaxis directs cell migration parallel to the EF and towards a preferential electrode. However, the internal cellular mechanisms affected by the external EF are not well understood. The goal of this work is to introduce a numerical framework for modelling electrotaxis by calculating...
Making diagnostic measurements available to the widely geographically spread populations in developing countries is a challenge which is unlikely to be met by the technology used in the west. Multi-frequency electrical impedance techniques are attractive in this context as the instrumentation is relatively simple and research has demonstrated application in cardiac and respiratory medicine and in...
A nanopore test circuit is proposed for single-strand DNA sequencing, which allows real-time sensing of the electric conductance of individual sections of a DNA strand as it is pulled through the nanopore by an electric current at a controlled speed. The test circuit is based on a planar microchamber with a nanochannel drilled through its multilayer graphene electrode by an electron beam. The nanochannel...
Compact measurement setup and test structure for nanosecond electroporation of biological cells were demonstrated. The test structure was based on a coplanar waveguide with a defected ground structure that afforded broadband impedance match with little dispersion or parasitic. The defected ground structure with a 10-µm gap formed a microchamber to readily accept biological solutions and to allow the...
Spinning Electric Vector Analyzer, SEVA-INTEGRAL, is designed for wide-band operation exploration of natural spinning electric fields. It is believed that spinning fields trigger physical processes, which then make a considerable effect on the origination of geo-pathogenic zones, GPZ. Experiments on the influence of electric rotation in fundamental physical and biological processes have revealed considerable...
We present a novel Address-Event Representation (AER) transmitter circuit to communicate pulses of neural activity (spikes) within a neuromorphic system. AER circuits allow an ensemble of neurons to achieve large scale time-multiplexed connectivity through a shared communication channel. Our design makes use of token-ring mutual exclusion where two circulating tokens in a 2D array of neurons provide...
We present here an electric circuit model that fits the behavior of iridium oxide coated electrodes when tested in vitro and in vivo. Our objective is to understand the interface between the active iridium oxide and the biological tissue. In order to do that we have first measured the impedance and the cyclic voltammetry in five electrodes which we later implanted in the hippocampi of rodents. While...
Confluent monolayers of cells in culture media are usually fragile and are susceptible to mechanical disruption. To assess the growth and migration of the cells towards recovery, the mechanical disruption is often done deliberately to perform wound healing assay. In such analysis, after a scratch in the cell monolayer, electrical characterization has been done to provide related quantitative description...
In this presentation, we will review and discuss recent advances in the research of wireless telemetry for medical applications in our group at UT-Arlington, particularly those based on a similar platform for in vivo monitoring of physiological parameters. System for recording ECoG signals in brain, recording in vivo gastric myoelectric activities in stomach, sensing in vivo strain variations in bladder,...
We investigate the molecular mechanism of inherited arrhythmias using a multiscale model. The model has numerous parameters some of which are estimated with voltage clamp data. Errors in the estimation of parameters have a dramatic effect on the investigation of the mechanism of arrhythmias. In some cases, these errors may prevent seeing the creation of a premature cardiac beat. We present an analysis...
Skin impedance is an excellent surrogate marker of skin permeability. Physical and chemical modalities that serve to increase skin permeability have direct applications in transdermal drug delivery. We have shown that the electrical impedance of skin, and consequently its permeability, can be changed by up to 60% by uniaxial stretching. This is of significant because electrical impedance has been...
The dynamic-clamp electrophysiological technique allows the mimicking of the electrical effects of ion channels embedded into the membrane of an intracellularly recorded cell. Dynamic-clamp relies on the establishing of a loop between the injected current and the recorded membrane potential. In this work, a real-time dynamic-clamp system was implemented on a Field Programmable Gate Array (FPGA). The...
Nowadays The research of electrophysiology signal has attracted much attention in clinical discipline. Original experiment record of electrophysiology is significant for further research, especially for the study of Channelopathy. It is difficult to repeat this experiment because of the special cases or the restrictions of the experimental equipment and the cost of experiment. Therefore, it is necessary...
Hydrogels are being fabricated for use in many tissue engineering applications. In order to advance the field, material properties must be characterized to determine the most desirable attributes. The data presented shows the importance of both surface charge and mechanical properties on dorsal root ganglia neurite extension.
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