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Non-invasive blood glucose measurement is a crucial challenge in both academic and industry communities. Currently, most of non-invasive solutions are developed based on optical signals. However, their accuracy is still far from clinical requirements if these measured optical signals directly used to estimate corresponding glucose levels. To solve this challenge, a novel Back-propagation Monte Carlo...
Chronic disease management currently requires frequent withdrawal of bodily fluids to assess biomolecule levels and are associated with patient discomfort and noncompliance. Thus, a need exists for less invasive, on-demand biochemistry monitoring. Our lab has investigated poly(2-hydroxyethyl methacrylate) (pHEMA) hydrogels functionalized with glucose oxidase and palladium benzoporphyrin phosphors...
Optical coherence tomography (OCT) is a noninvasive imaging technology. It is one of several approaches bases for developing noninvasive blood glucose meter. OCT systems offers advantages in signal to noise ratio, high resolution and good depth of penetration. The OCT technique is based on the measurement of changes induced by glucose in the optical properties of the dermis skin layer. Blood glucose...
In this study, in order to help the blood glucose measurement on diabetic patients by using optical activity of glucose and the changing polarization of light under a magnetic field, an optical system determining the glucose concentration in the blood phantom and operating in-vitro conditions is being developed [4,5]. In that designed optical system, the alteration of the polarization angle mechanically...
Diabetes mellitus is one of major of ill health in the world. One of the popular topics in biomedical optics applications is using the near infrared spectra for non-invasive blood glucose measurement. Nonetheless, the most researches of blood glucose concentration measurement focus on the diffuse reflection either in domestic or overseas, the research of transmission is rare. In this paper, by the...
Recent achievements of tissue immersion optical clearing technique are demonstrated. The specific features of optical clearing of tissues in the visible/NIR and terahertz ranges are underlined. In vitro, ex vivo, and in vivo studies of human and animal tissues are presented.
The paper examines the use of photoacoustic spectroscopy (PAS) for making continuous non-invasive blood glucose measurements. An apparatus for performing photoacoustic (PA) measurements is constructed and the technique is verified in vitro and in vivo through measurements on glucose solutions and live tissue. The signal amplitude is observed to increase with the glucose concentration in both cases...
In this work, we propose an architecture for optical detection based analyzer to be integrated with Digital Microfluidic Biochips (DMFB). A reference memory has been integrated with the device to define pre-characterized data for the multiple reference levels. The architecture has been developed towards the implementation of the fuzzy based control of the process flow for extending the analysis to...
Digital Microfluidic Biochips (DMFB), a promising platform for Lab-on-chip systems are capable of automated biochemical analysis targeted for medical diagnostics and other biochemical applications. The inherent nature of reconfigurability and scalability enables the device to integrate multiple bioassay protocols within the same array for simultaneous execution. Each execution of Bioassay involves...
Detection and analysis are major tasks for biochemical analysis required to be performed in digital microfluidic systems. With the development of heterogeneous photonic component integration technologies it has become possible to integrate miniaturized optical sensing technologies with the Microfluidic systems. This enables complex optical detection functions to be incorporated within the microfluidic...
Optically-induced dielectrophoresis (ODEP) has been widely used for manipulation of micro particles and cells. However, it requires a complicate medium replacement process before one could manipulate cells. For instance, 0.2M sucrose was used to generate enough ODEP forces for cell manipulation when the cells could be centrifuged to get rid of the original solution Dulbecco's modified eagle medium...
Our purpose is to characterize the Brownian motion of glucose concentration in Intralipid solution using time-domain optical coherence tomography (OCT) incorporated with wavelet power spectrum. The results show that the standard deviation (SD) of frequency in the superficial layer, linearly proportional to Brownian diffusion coefficient, is independent of the depth. Our preliminary results demonstrate...
In this study, we use porous silicon based microcavity to detect glucose solution concentration in real time. With the aid of a portable fiber spectrophotometer, we recorded the changing of resonance dip position of the porous silicon microcavity in real time as a function of the changing of the concentration of the infiltrated glucose solution. Results show that the sensor has rapid response of 25...
This study reports the noninvasive, wide-field and rapid measurement of refractive index (RI) difference for diagnosis of cell's pathological state by utilizing light scattering with evanescent wave illumination. The RI of an abnormal cell is different from that of a normal one because of the change in the ratio of each intracellular component, thus RI measurement can be an effective approach for...
A preliminary investigation into the design of a near-infrared (NIR) optical bio-implant for accurate measurement of blood glucose concentration is reported. The use of an array of electrically pumped vertical-cavity surface-emitting laser (VCSEL) diodes at specific wavelengths for high-power narrow single-frequency emission leads to a high signal-to-noise ratio (SNR) in the measured NIR absorption...
Diagnostic imaging techniques are commonly used in a clinical setting for the detection of abnormalities. Optical coherence tomography (OCT) is a relatively novel imaging technique capable of performing structural and functional analysis of various tissue specimens. When structural imaging is limited by the resolution of the system, functional imaging, e.g. through the quantification of the permeability...
Diabetes is a disease of concern, which affects vital organs of body. In order to prevent complications, frequent glucose measurement is necessary. This paper presents a possible methodology for noninvasive blood glucose measurement using photoacoustic (PA) method. Although encouraging results have been obtained using the developed system, certain other error sources like melanin content of skin,...
Raman mapping was used to determine the distribution of fats inside of adipocytes and human mesenchymal stem cells during adipogenesis. This proved to be a successful way of mapping the lipid distribution within the cells because of the strong C-H stretching bands of the fats inside the lipid droplets. Furthermore using deuterated glucose in the cell culture medium it was possible to distinguish any...
In this study, a new portable type Self-Monitoring Blood Glucose (SMBG) device, which is driven automatically from the blood sampling to the blood glucose measurement, is developed to establish the point-of-care technology in the ubiquitous medical care. It aims to overcome human errors due to the complicated manual operation of commercial SMBG devices. In this study, I mainly discuss the development...
An optical system for monitoring glucose with a means of compensating for local oxygen variations is described. Measurements of sensor response to glucose under varying oxygen levels indicate a strong dependence of the optical response on ambient oxygen. The two-probe approach enables simultaneous monitoring of luminescence lifetime of microparticle sensors with a compact optical system. Glucose tracking...
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