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Photodynamic therapy (PDT) is a light-based treatment modality that has shown promise for treatment of early stage oral lesions and potential to be adaptable for successful implementation in resource limited settings. To operate in such conditions a PDT light source must be engineered to be robust and portable, with flexible fiber optic light delivery that provides stable output in the desired spectral...
Biophotonics, the study of light propagation through living tissue, is important for many medical applications ranging from imaging and detection through therapy for conditions such as cancer. Effective medical use of light depends on simulating its propagation through highly-scattering tissue. Monte Carlo simulation of photon migration has been adopted as the "gold standard" for its ability...
Photodynamic Therapy or PDT is a treatment that uses light-sensitive drugs known as photosensitizing agents or PSAs in conjunction with a light source to eradicate harmful cells. While there have been successful applications of PDT in treating many varieties of cancer, it is still considered highly experimental. However, PDT to treat skin afflictions including acne, psoriasis, and actinic keratosis...
Predicting the therapeutic outcome of photodynamic therapy (PDT) requires knowledge of the changes in photosensitizer concentration during the treatment. To investigate this, in vitro experiments were performed in which CT26 cells derivated from colon carcinoma tumor of BALB/c mice were injected subcutaneously in the right flank of mice. 5-aminolaevulinic acid is injected intraperitoneally at a dose...
Photodynamic Therapy (PDT) is a recent treatment modality that allows malignant tissue destruction. The technique provides a localized effect and good cosmetic results. The application of PDT is based on the inoculation of a photosensitizer and the posterior irradiation by an optical source. This radiation chemically activates the drug and provokes reactions that lead to tissue necrosis. Nowadays...
Conventional endoscope-guided photodynamic therapy (PDT) suffers mostly from motion artifacts, therefore expert hand-eye coordination was always needed during manual operations. In this paper we introduced a visual servo scheme to handle the tracking problem between the focused area and the targeted lesions. The scheme is consisted of real-time feature matching, relative motion cancellation and real-time...
Photodynamic therapy (PDT) is a method of treating cancer that combines light and light-sensitive drugs to selectively destroy cancerous tumours without harming the healthy tissue. The success of PDT depends on the accurate computation of light dose distribution. Monte Carlo (MC) simulations can provide an accurate solution for light dose distribution, but have high computation time that prevents...
In this report the results of laser-induced tissue oxygenation for elimination of tissue hypoxia in solid tumors are presented. It is predicted that the efficiency of PDT as well as radiation and chemotherapeutic methods could be significantly increased due to extra supply of tumor tissue by free molecular oxygen. The results of mathematical modeling the kinetic of oxygen distribution into tissue...
Objective: Study the influence of Hematoporphyrin Monomethyl Ether (HMME) concentration in blood vessel in a rather short time on photodynamic therapy (PDT) microvascular effect by mathematical modeling and animal experiment. Methods: The yields of singlet oxygen in blood vessel in a short time in different animal were simulated by mathematical model, and the yields of singlet oxygen in Leghorn Cocks...
Active oxygen series, especially singlet oxygen (1O2), often need to be detected, such as detection of Photodynamic therapy (PDT), seed vigour and plant stress, and so on. Chemiluminescence(CL) is high sensitive to detect active oxygen and can be easily realized with a conventional optical detector. It is utilized in many fields. Fluoresceinyl Cypridina Luciferin Analog (FCLA) is a high sensitive...
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