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The efficacy of 15nm gold nanoparticles (AuNP) coated with Yersinia pestis F1-antigen, as an immunogen in mice, has been assessed. The nanoparticles were decorated with F1-antigen using N-hydroxysuccinimide and N-(3-dimethylaminopropyl)-N′-ethylcarbodiimide hydrochloride coupling chemistry. Mice given AuNP-F1 in alhydrogel generated the greatest IgG antibody response to F1-antigen when compared with...
Plague, which is initiated by Yersinia pestis infection, is a fatal disease that progresses rapidly and leads to high mortality rates if not treated. Antibiotics are an effective plague therapy, but antibiotic-resistant Y. pestis strains have been reported and therefore alternative countermeasures are needed. In the present study, we assessed the potential of an F1 plus LcrV-based vaccine to provide...
L'épidémie de peste qui s'est déroulée récemment en Inde a rappelé au monde que cette maladie était encore bien présente et faisait toujours aussi peur. La peste, qui avait disparu d'Inde depuis presque 30 ans, a refait son apparition sous sa forme bubonique à Beed (état du Maharastra) en août 1994, puis sous sa forme pulmonaire à Surat (état du Gujarat) un mois plus tard. Le nombre total de cas suspects...
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