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In this paper, a radiomics approach was proposed to determine whether the tumor heterogeneity of non-small cell lung cancer (NSCLC), which was measured by the texture on computed tomography (CT), could make an independent prediction of overall survival. A primary dataset contained 72 patients (mean survival, 15.9 months) with pathologic diagnosis of NSCLC and a validation dataset contained 67 NSCLC...
Non-small cell lung cancer (NSCLC) constitutes the most common type of lung cancer and is frequently diagnosed at advanced stages. Clinical studies have shown that molecular targeted therapies increase survival and improve quality of life in patients. Nevertheless, the realization of personalized therapies for NSCLC faces a number of challenges including the integration of clinical and genetic data...
Objective: To evaluate the clinical efficacy and safety of cytokine-induced killer (CIK) cells immunotherapy in combination with platinum chemotherapy and Xiaoji decoction in patients with advanced stage non-small cell lung cancer (NSCLC). Methods: Patients with advanced stage NSCLC were randomly assigned to Group A (platinum chemotherapy plus xiaoji decoction) and Group B (platinum chemotherapy plus...
Lung cancer is the leading cause of cancer-related deaths worldwide. Classification and characterization of cancer treatment strategies are essential in the current medical era. Gene mutations and their altered expressions is the base of cancer development. Analyzing these gene mutations and gene expression data for the phenotypic classification of lung cancer is proposed in this paper. Genomic and...
Patients with advanced or metastatic non-small cell lung cancer (NSCLC) may get benefit from epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) but eventually develop acquired resistance to these. Here, we report a case of advanced NSCLC patient who developed resistance to gefitinib but then got benefit from erlotinib. The patient first received palliative chemotherapy, after...
MicroRNAs are small non-coding RNAs of 21-25 nucleotides that might impact regulatory mechanisms in cancer. Due to their influence on cell physiology, alteration of miRNA regulation can be implicated in carcinogenesis and disease progression. In general, one miRNA is predicted to regulate several hundred genes, and as a result, miRNA profiling could serve as a better classifier than gene expression...
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