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A versatile 4-channel bipotentiostat system for biochemical sensing is presented. A 1pA current resolution and 8 kHz bandwidth are suited for amperometric detection of neurotransmitters released by cells, monitored in a smart microfluidic culture chamber. Multiple electrochemical measurements can be carried out on arrays of microelectrodes. Key design issues are here discussed along with the results...
The successful development of neural prostheses requires an understanding of the neurobiological bases of cognitive processes, i.e., how the collective activity of populations of neurons results in a higher level process not predictable based on knowledge of the individual neurons and/or synapses alone. We have been studying and applying novel methods for representing nonlinear transformations of...
Neurons transform a series of presynaptic spikes into a series of postsynaptic spikes through a number of nonlinear mechanisms. A nonlinear model with a dynamical threshold was built using a Volterra Laguerre kernel method to characterize the spike train to spike train transformations of hippocampal CA1 pyramidal neurons. Inputs of the model were broadband Poisson random impulse trains with a 2 Hz...
Olfactory system can distinguish thousands of odors. In order to utilize biological olfactory neurons as sensitive material of electronic nose, this article reports an olfactory neurochip as real bionic technique for odorants detection. Effective cultures of olfactory receptor neurons and olfactory bulb cells on the chip have been achieved. Using light-addressable potentiometric sensor (LAPS) as sensing...
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