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This paper investigates the enhancement of sensitivity of variable incidence angle LSPR biosensor by monitoring biomolecular interactions of biotin-streptavidin with gold thin film. The investigation is carried out by means of introducing an additional layer of graphene sheet on top of gold layer (graphene biosensor) and using different coupling configuration of laser beam. The sensitivity, which...
We explore the sensitivity enhancement of label-free detection based on localized surface plasmon resonance using surface-relief nanograting structures. A nanograting structure was modeled, so that target molecular interactions are localized in hot spots of the near fields. The nanograting structure was optimized numerically for the highest enhancement of sensitivity with hybridization between complementary...
A novel optical biosensor assembled with gold colloidal nanoparticles on gold plate surface has been constructed via 1,4-dithiothreitol and L-cysteic acid for detection of bio-molecules like antigen, antibody protein and DNA plasmid, which exhibited distinct optical properties of localized surface plasmon resonance (LSPR). The prepared nano gold sol were characterized by using UV-Vis absorption spectroscopy,...
A white-light source operated polymer-based micromachined Fabry-Perot Interferometer (muFPI) with embedded nanostructures in its cavity is reported for the first time. The nanostructures inside the cavity are Au-coated nanopore-plasmonic substrate, forming an Au-nanopore-FPI. It offers at least three advantages over a traditional muFPI including the increased sensing surface area, the extended penetration...
A novel optical biosensor with gold surface bound silver nanoparticles has been constructed for detection of bio-molecules like antigen, antibody protein and DNA plasmid, which exhibited distinct optical properties of localized surface plasmon resonance (LSPR). The silver colloidal nanoparticles were prepared by using sodium borohydride reduction of silver nitrate and characterized by using UV-vis...
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