The Infona portal uses cookies, i.e. strings of text saved by a browser on the user's device. The portal can access those files and use them to remember the user's data, such as their chosen settings (screen view, interface language, etc.), or their login data. By using the Infona portal the user accepts automatic saving and using this information for portal operation purposes. More information on the subject can be found in the Privacy Policy and Terms of Service. By closing this window the user confirms that they have read the information on cookie usage, and they accept the privacy policy and the way cookies are used by the portal. You can change the cookie settings in your browser.
The problem of finding the minimum input norm required to bring a dynamical system from an arbitrary initial state to a given end-point constraint set under specified state constraints, in a finite time interval, is considered. Even when there exists a control input which achieves the constraints, there may not be one with a minimum norm. For input-affine systems, it is shown that there is an admissible...
Live-Cell Assays are used to study the dynamic functional cellular processes in high-content screening of drug discovery processes. One class of tasks in this application is the tracking of cells and the description of the events and the changes in the cell characteristics. The large amount of data requires fast processing algorithms and compact object and event descriptions. We propose in this paper...
In order to design life saving drugs, such as cancer drugs, the design of protein or DNA structures have to be accurate. These structures depend on multiple sequence alignment (MSA). MSA is a combinatorial optimization problem which is used to find the accurate structure of protein and DNA sequences from the existing sequences. In this paper, we have proposed a new iterative progressive alignment...
Liposomal hydrogel formulations of lidocaine hydrochloride(LDH)have been prepared and drug percutaneous permeation and release properties in vitro have been evaluated. An optimal hydrogel prescription with carbopol as base involved permeation enhancers as polyethylene glycol (PEG-400), Azone, poloxamer and propylene glycol was screened in vitro. Percutaneous permeation kinetic models of LDH in three...
In order to determine the effect of the amido and hydroxyl of chitosan on antioxidant activity, a series of N-deacetylated chitosan with a degree of deacetylation (D.D.) ranging from 45% to 95% were prepared using region selective N-acetylation of chitosan. Their carboxymethyl derivatives (CMC) were also synthesized according to previous method. The antioxidant activity was evaluated on the basis...
Background: suicide is a serious public health problem in many provinces in Iran such as Kermanshah province. Objective(s): to determine the incidence of suicide & its trend among kermanshah rural population and its risk factors. Methods: In this descriptive cross-sectional study, all cases of attempted suicide over a period of 7 years (2000-2006) have been investigated. There were a total number...
Saikosaponin D is a saponin extract derived from several species of Bupleurum (Umbelliferae), which is used for the treatment of various liver diseases in traditional Chinese medicine. In this study, we report that Saikosaponin D inhibits the cell growth of human lung cancer cell line A549 and provide a molecular understanding of this effect. The results showed that Saikosaponin D inhibited the proliferation...
The aim of this paper is to explore the relativity between tumor and kidney damage. This method presents the pathogeny, nosogenesis, clinical manifestation, treatment and prognosis of kidney damage what is resulted from tumor in addition to kidney through two cases of clinical data about patient suffering from kidney damage associated with tumor. It is concluded that there is a certain inherent link...
Young shoots, collected from about 100 trees, were sprayed on 10 mg/L Sumiseven (S3307) and 100 mg/L Gibberellin (GA3) separately., and investigated for their contents of 10-deacetyl Baccatin III (10-DAB), Baccatin III and Paclitaxel (Taxol) at different time in order to get a better understanding of the synthesis mechanism of taxol in vitro. The result shows that S3307 and GA3 change the metabolism...
Nanoparticles with various formations were produced based on ionic gelation process between chitosan and tripolyphosphate (TPP) by using bovine serum albumin (BSA) as a model drug. Their average diameter was 300-700 nm with the examination of laser granularity analyzer. The morphologies were examined with optical microscope and TEM. FTIR was used to study the structure characterization between chitosan...
To study the effect of saponins of asparagus on apoptosis and the variations of Caspase-8,9,3 activity in the process of asparagus induced apoptosis in HepG-2. Cell was administrated with different concentrations of asparagus at different time, the apoptosis rate was determined by FCM with AV-PI staining, the morphology was observed by electron microscopy, Caspase-8,9,3 activities was measured by...
3-(4'-fluorophenyl)-5-(2'-sulfonylphenylazo)-rhodanine (4FRASP) firstly synthesized by the authors was used as chemiluminescence (CL) reagent. In acidic medium, CL was observed when amoxicillin was injected into the mixture of 4FRASP-potassium permanganate. Based on this phenomenon, a flow injection CL method was established for the determination of amoxicillin. The CL intensity was correlated linear...
The performance of AMCBR reactor was monitored at a HRT of 1.5 days and at a organic loading rate of 3.2 kgCOD/m3day. The removal efficiencies of antibiotics were 89%, 90%, 91% and 88% respectively, after 30 days of operation period. The COD removal efficiencies were 90%, 91%, 92% and 89%. The total methane production was 10.841 l/day, while the methane percentage of total gas were 56%, 60%, 70%,...
beta-lactam antibiotics are the most commonly used antibiotics which cause bacterial cell lysis by inhibiting the enzyme responsible for the cell wall synthesis. Production of beta-lactamase enzyme, which catalyzes the hydrolysis of beta-lactam ring of beta-lactam antibiotics is the most common mechanism of bacterial resistance. beta-Lactamase Inhibitory Protein (BLIP), is an effective inhibitor of...
Amphiphilic poly(methyl methacrylate)-b-poly(acrylic acid) (PMMA-b-PAA) copolymers with 4 and 6 arms were synthesized by atomic transfer radical polymerization (ATRP). The polymers were characterized by GPC, H-NMR and FTIR analysis. Polymer samples synthesized at various molecular weights between 18-80 kDa were investigated in terms of maximum loading capacity and critical micelle concentration by...
Chemotherapy is a well-established medical practice for treatment of various types of cancers. A chemotherapy programme is prepared by a specialist doctor. Preparation, scheduling and management of chemotherapy programmes, especially when many patients with competing requirements are involved, are complicated tasks. A chemotherapy programme involves a number of cycles, each cycle involving application...
Concentration gradients have important applications in chemical and biological studies. Here we have achieved rapid generation of spatially and temporally controllable concentration gradients of diffusible molecules (i.e. proteins or toxins) in a portable microfluidic device. The formation of the concentration gradients was initiated by a passive-pump-induced forward flow and further optimized during...
To study the effect of saponins of asparagus on apoptosis and the variations of Caspase-8, 9, 3 activity in the process of asparagus induced apoptosis in HepG-2. Cell was administrated with different concentrations of asparagus at different time, the apoptosis rate was determined by FCM with AV-PI staining, the morphology was observed by electron microscopy, caspase-8,9,3 activities was measured by...
Due to their high quantum yields of singlet oxygen and excellent light-induction attributes, hypocrellins have recently received much research attention. Hypocrellins, including hypocrellin A (HA) and hypocrellin B (HB), have relatively low absorption in the phototherapeutic window (600-900 nm) due to their longest wavelength absorbance band at 584 nm. To solve this problem, amino groups are introduced...
We derive a one-period look-ahead policy for online subset selection problems, where learning about one subset also gives us information about other subsets. The subset selection problem is treated as a multi-armed bandit problem with correlated prior beliefs. We show that our decision rule is easily computable, and present experimental evidence that the policy is competitive against other online...
Set the date range to filter the displayed results. You can set a starting date, ending date or both. You can enter the dates manually or choose them from the calendar.