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Hypertension is the most common cardiovascular disease. The prevalence of hypertension increases with advancing age; for example, about 50% of people between the ages of 60 and 69 years old have hypertension, and the prevalence is further increased beyond age of 70. Many angiotensin converting enzyme (ACE) inhibitors are known to be useful in the treatment of hypertension. The search for ACE inhibitors...
To study the effect of saponins of asparagus on apoptosis and the variations of Caspase-8, 9, 3 activity in the process of asparagus induced apoptosis in HepG-2. Cell was administrated with different concentrations of asparagus at different time, the apoptosis rate was determined by FCM with AV-PI staining, the morphology was observed by electron microscopy, Caspase-8, 9, 3 activities was measured...
AMP-activated protein kinase (AMPK) is a metabolite- sensed protein kinase in various eukaryotes. The activated AMPK regulates important proteins which cause diabetes, obesity, metabolic aberrant, and also breast cancer. In this study, the yeast AMPK structure was used as a template to model the human AMPK structure. By homology modeling, the reliable AMPK structure was built, and the active binding...
Hiv-1 integrase (IN) is an important and validated target for drug design. The diketo acid (DKA) compounds were identified as potent inhibitors for IN. Due to the IN-5citep complex structure has been resolved, it can give hints for IN-DKAs binding mode. A comprehensive receptor based pharmacophore model based on the reasonable binding mode is feasible for developing new and better inhibitors. In this...
Heroin addiction caused oxidative stress was testified for the first time in mice. After administered with heroin, mice not only showed decreased total antioxidant capacity as well as antioxidant enzymes such as, SOD, CAT and GPx in brain, but also include oxidative damage of DNA, protein and lipid. On the other hand, exogenous antioxidants could restrain the oxidative stress, even alleviate withdrawal...
HCV (Hepatitis C virus) that the NS3 protease and NS5B RNA-dependent RNA polymerase (RbRp) which the enzymes for virtual replication. HCV plays an important role that to cause the chronic and liver diseases. The computer aided drug design (CADD) that is the new method to design the new molecules as like the drugs from the potent compounds. We took the program of Discovery Studio 2.0 and the scoring...
beta-lactam antibiotics are the most commonly used antibiotics which cause bacterial cell lysis by inhibiting the enzyme responsible for the cell wall synthesis. Production of beta-lactamase enzyme, which catalyzes the hydrolysis of beta-lactam ring of beta-lactam antibiotics is the most common mechanism of bacterial resistance. beta-Lactamase Inhibitory Protein (BLIP), is an effective inhibitor of...
To study the effect of saponins of asparagus on apoptosis and the variations of Caspase-8, 9, 3 activity in the process of asparagus induced apoptosis in HepG-2. Cell was administrated with different concentrations of asparagus at different time, the apoptosis rate was determined by FCM with AV-PI staining, the morphology was observed by electron microscopy, caspase-8,9,3 activities was measured by...
Molecular docking technology is an important tool in computer-aided drug discovery and structure prediction for the protein-ligand complex. In this work, based on the analysis of the algorithm of the widely used the docking program AutoDock, we proposed a hybrid parallel method using the message passing interface (MPI) library. The modified programs were applied to dock the small molecule XK263 to...
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