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Drug resistance is a frequent clinical problem that seriously reduces the efficacy of many chemotherapy agents. In this study, the effect of micellar encapsulation using poly(L-lactide)-vitamin E TPGS (PLA-TPGS) copolymer on intracellular distribution of doxorubicin was studied in vitro. As our results, doxorubicin can be encapsulated successfully into PLA-TPGS formed micelle with a uniform particle...
The model of a novel drug delivery device of gastrointestinal microcapsule in a gas pressure driving way is proposed. The model experiments have been carried out to investigate into the main factors impacting on the performance of capsule, such as ultrasonic frequency, the relationship between the quantity and reaction time of the selected reactants, the relationship between the carried drug capacity...
Liposomal hydrogel formulations of lidocaine hydrochloride(LDH)have been prepared and drug percutaneous permeation and release properties in vitro have been evaluated. An optimal hydrogel prescription with carbopol as base involved permeation enhancers as polyethylene glycol (PEG-400), Azone, poloxamer and propylene glycol was screened in vitro. Percutaneous permeation kinetic models of LDH in three...
This paper presents a structure forming scheme that is capable of remotely shaping magnetic composites into desired geometries. The magnetic composites, which are made up of fine ferrite particles in PDMS pre-polymer matrices, are injected into controlled magnetic fields and deformed by the induced magnetic and interfacial interactions. Directed by the magnetic fields, the injected composites can...
Amphiphilic poly(methyl methacrylate)-b-poly(acrylic acid) (PMMA-b-PAA) copolymers with 4 and 6 arms were synthesized by atomic transfer radical polymerization (ATRP). The polymers were characterized by GPC, H-NMR and FTIR analysis. Polymer samples synthesized at various molecular weights between 18-80 kDa were investigated in terms of maximum loading capacity and critical micelle concentration by...
Poly(lactic acid)-poly(ethylene oxide)-poly(lactic acid) (PLA-PEO-PLA) triblock copolymer hydrogels are a promising biomaterial, with applications to drug delivery and cell scaffolds for tissue engineering. Using L-lactic acid gives PLLA-PEO-PLLA, which has stereoregular end blocks. The resulting system forms lamellae with hydrophobic semi crystalline domains of PLLA with hydrophilic domains of PEO...
Helical Rosette Nanotubes (HRN) are novel biomimetic self-asssembled supramolecular, whose DNA base-pairs (G & C) can solidify in water under physiological conditions. Due to electrostatic force and interactions effects, a stable stack with an inner channel 11aring in diameter is formed. Because of their hollow structure and amino side chains (lysine), they can either trap or be functionalized...
Various silk based drug delivery systems were designed to exploit silk's novel material properties in order to attain slow, sustained, controlled release. Using the small molecule model drug adenosine, release profiles from various silk delivery systems were characterized in vitro. The therapeutic potential of the implants was validated in a dose response study in the rat model of kindling epileptogenesis...
The use of carbon nanotubes (CNTs) as vectors for targeted drug delivery was recently considered, thanks to their ability to permeate the cellular membrane which, instead, results highly refractory to transfer with other vectors (viral and not viral). Our project is devoted to define and characterize a CNTs based nanocompound for gene-moduling, with the final aim of complementing defective functions...
After 45 years of unfortunate delay, nanodiamond particles having 4.8±0.7 nm in diameter are now emerging as one of the most promising candidates for a general purpose material in nanotechnology for the reasons of (1) low cost, (2) non-toxicity, (3) high crystallinity, and (4) versatile maneuverability. (1) The raw material is a TNT-based war explosive, once most popular, over-produced but now becoming...
An effective cytotoxic agent for cancer therapy should demonstrate reduced toxicity by having an increased specificity towards cancer cells. To address this challenge, several research groups have investigated conjugating various cytotoxins to the iron transport protein transferrin (Tf), since its receptor (TfR) is overexpressed on the surfaces of cancer cells. Tf undergoes receptor-mediated endocytosis...
The Control Advance Moving Average Controller, a modification of the Minimum Variance Self-Tuning Controller, Was used to simultaneously control Mean Arterial Pressure and Cardiac Output in anesthetized dogs. By varying the infusion of sodium nitroprusside and dobutamine the controller successfully lowered the mean arterial pressure and raised the cardiac output to preset setpoints.
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