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Cell migration is a key step for deterioration of many in situ or metastasis malignant tumours. Tumour anti-migration is a promising strategy to treat cancer, but corresponding drugs developed under such a strategy are still in dire poverty, partly due to the lengthly process of drug trials and approval required by the US Food and Drug Administration (FDA). Given there are thousands of FDA approved...
We present a model written in BlenX language describing the lung tumor size changes over the time course of chemotherapy in human patients that are treated with gemcitabine and carboplatin.
In this paper, optimal drug schedule for patients in progressive cancer phase who take the drug through infusion pump is obtained. An objective of control is reducing tumor cell numbers effectively while minimizing total amount of drug regimen. This is done because of the known serious side effects and major damages resulting from chemotherapy. Chemotherapy brings about weakness of the patient's immune...
In this paper, we propose a stochastic simulation to model and analyze cellular signal transduction. The high number of objects in a simulation requires advanced visualization techniques: first to handle the large data sets, second to support the human perception in the crowded environment, and third to provide an interactive exploration tool. To adjust the state of the cell to an external signal,...
The potential of cancer multilevel modeling has been particularly emphasized over the past years. Integration of multiscale experimental and clinical information pertaining to cancer via advanced computer models seems to considerably accelerate optimization of cancer treatment in the patient individualized context. However, a sine qua non prerequisite for such models to reach clinical practice is...
Solid tumors must recruit new blood vessels for growth and maintenance. Discovering drugs that block this tumor-induced development of new blood vessels (angiogenesis) is an important approach in cancer treatment. However, the complexity of angiogenesis and the difficulty in implementing and evaluating rationally-designed treatments prevent the discovery of effective new therapies. This paper presents...
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