The Infona portal uses cookies, i.e. strings of text saved by a browser on the user's device. The portal can access those files and use them to remember the user's data, such as their chosen settings (screen view, interface language, etc.), or their login data. By using the Infona portal the user accepts automatic saving and using this information for portal operation purposes. More information on the subject can be found in the Privacy Policy and Terms of Service. By closing this window the user confirms that they have read the information on cookie usage, and they accept the privacy policy and the way cookies are used by the portal. You can change the cookie settings in your browser.
A database to store genetic information of Alzheimer's Disease (AD) patients is necessary to spur research in development of drugs suitable for local patients. Works by Abdul Rahman et. al. had created this database. However, the database contains large amounts of redundant genetic data. The storage of uncompressed data is suboptimal because it would consume large storage space as well as slow down...
This paper presents a computational approach to HIV Drug discovery using rough set based rule induction. Since conventional drug discovery is a time consuming process in which drugs are discovered either by chance or by screening the natural products, alternative methods were required to hasten the process in order to abridge the demand and supply gap. Chemoinformatics, providing novel methodologies...
The work is motivated by real-world applications of detecting Adverse Drug Reactions (ADRs) from administrative health databases. ADRs are a leading cause of hospitalization and death worldwide. Almost all current postmarket ADR signaling techniques are based on spontaneous ADR case reports, which suffer from serious underreporting and latency. However, administrative health data are widely and routinely...
Mutant protein hSKCa3 responsible for Schizophrenia is taken from NCBI's Entrez database; its 3D structure is determined by homology modelling. The conotoxin protein is taken from NCBI's Entrez database & its 3D structure is established. The structure of Withanolide is determined and docked with conotoxin protein; this combination is docked with hSKCa3 protein, hence establishing a remedy.
One of the main tasks of KDTCM (knowledge discovery in traditional Chinese medicine) is discovering novel paired or grouped drugs from Chinese medical formula database. Paired or grouped drugs, which are special combinations of two or more drugs, have strong efficacy. Association rule mining is used by reason of the large number of association relationships among various kinds of drugs. However, association...
Web database is a convenient way of sharing and retrieving data as well as a key component of the information system infrastructure of today's modern research. In medicine, Web databases on various diseases are valuable tools to facilitate the search for effective treatment. Alzheimer's disease (AD) is a neurodegenerative disease that has received significant focus in research worldwide. Currently,...
One of the most well known successes of Inductive Logic Programming (ILP) is on Structure-Activity Relationship (SAR) problems. In such problems, ILP has proved several times to be capable of constructing expert comprehensible models that help to explain the activity of chemical compounds based on their structure and properties. However, despite its successes on SAR problems, ILP has severe scalability...
We have developed an integrated, rational drug-design system consisting of four programs: CAVITY, FOUNDATION, DBMAKER, and SPLICE. The first two programs are utilized to characterize the active site and retrieve complementary molecular fragments. Databases containing 3D structures for searching can be generated using the program DBMAKER along with CONCORD. Finally, the program SPLICE is used to edit...
Set the date range to filter the displayed results. You can set a starting date, ending date or both. You can enter the dates manually or choose them from the calendar.