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Summary form only given. Deoxyribonucleic acid (DNA) has become one of the most examined molecules on the planet. Scientist around the world have been trying to unravel its secrets for many purposes. For example, genetic information is currently used to raise better plants and animals, create enhanced pharmaceuticals for humans, and for gene therapy in medicine. Science as a whole has benefited from...
This paper presents feature extraction and estimations of multifractal measures for deoxyribonucleic acid (DNA) sequences, and demonstrates the intriguing possibility of identifying biological functionality using information contained within the DNA sequence. We have developed a technique that seeks patterns or correlations in the DNA sequence at a higher level. The technique has three main steps:...
Discovery of transcription factor binding sites (TFBSs) or DNA motifs in promoter regions of genes plays a key role in understanding the regulations of gene expression. In the past decade computational approaches, including evolutionary computation techniques, for searching for motifs have demonstrated good potential, and some results reported in literature are quite promising. Recently, some favorable...
Due to the enormous amount of data in DNA sequences to be processed, the computational complexity and speed are important issues to be considered. In this paper, a new integrative method is presented for predicting protein coding regions. We first establish a Takagi-Sugeno fuzzy model to identify the first nucleotide of a codon in coding regions, then the time-frequency characteristics of the output...
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