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Most new drug candidates generated during in vitro screenings turn out to be invalid after time-consuming and costly testing in animal models. Therefore, development of noninvasive, real-time, sensitive, and cost-effective tools with higher throughput for monitoring and early detection of drug efficacy in vivo is urgently needed. Of such techniques, optical molecular imaging provides many advantages...
Summary form only given. Using recent developments in construction of high field magnets, magnetic resonance spectroscopy has been integrated with magnetic resonance imaging for clinical use. Magnetic resonance (MR) spectra can be obtained from an image-defined volume of interest using a variety of magnetic resonance localization techniques. Recently, magnetic resonance spectroscopic imaging techniques...
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