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A novel stretchable Micro-Electrode Array (MEA) for biomedical applications with robust spiraled interconnects and radial micro-grooves for cell alignment is presented, enabling the unique combination of alignment, mechanical stimulation, and electrical characterization of living cells. Many of the problems normally associated with the fabrication of interconnects and electrodes on stretchable PDMS...
We report a 8-12-μm-diameter 210-μm-length penetrating silicon probe array assembled by vapor-liquid-solid (VLS) growth, for use in multi-site recordings of neuron spikes in a brain cortex. A 3-μm-diameter silicon probe-tip metalized with platinum (Pt)-black by the electroplating, exhibits low enough probe impedance of 103 kΩ and a more than 90% output/input ratio (1 kHz) for spike recordings. Through...
In this paper, a novel microelectrode array (MEA), with varying arrowhead shapes, is fabricated and evaluated for retinal prostheses. The proposed MEA has a total of 199 arrowhead-shaped microelectrodes, with heights ranging from 42 to 123.5 μm. This height variation allows each microelectrode to contact the spherical eyeball conformably and to approach the stimulation target retinal cells very closely...
A high-resolution PDMS-based conformable microelectrode array (cMEA) with integrated electronics is implemented. The cMEA is incorporated into individual layers of a nanofiber-based nerve regeneration scaffold to create a novel regenerative electrode scaffold (RES) capable of establishing a stable, high-resolution peripheral nerve interface. The device features a compact size with an enhanced signal-to-noise...
This paper proposes a novel light switchable microelectrode array (LSMA) for retinal prosthesis, which is performed with the photosensitive conductivity of hydrogenated amorphous silicon (α-Si:H) and has more advantages over the two major current retinal prosthetic categories. A simplified prototype is fabricated and related experimental results are obtained. Its current increases from 1μA in darkness...
One of the important challenges in designing Brain-Machine Interfaces (BMI) is to build implantable systems that have the ability to reliably process the activity of large ensembles of cortical neurons. In this paper, we report the design, fabrication, and testing of a polyimide-based microelectrode array integrated with a low-power amplifier as part of the Florida Wireless Integrated Recording Electrode...
This paper reports a fully batch-fabricated cochlear electrode array with built-in curl and stiffness control. The array is fabricated from stacked layers of parylene and metal with an integrated backing structure formed by parylene rings. The dual-function rings set the stiffness of the device and allow the array to be positioned inside the cochlea using a standard stylet wire approach. Metal-based...
As one of the basic concepts of the Chinese medicine, the theory of Meridians and Collaterals is lack of scientific demonstration so far. In order to verify the existence of Meridians and Collaterals, a method based on the electric technique and information theory is suggested, A specialized electrode array has been designed and an experimental scheme of signal stimulating and detecting was introduced...
This paper demonstrates a novel flexible carbon nanotubes (CNTs) electrode array for neural recording. In this device, the CNTs electrode arrays are partially embedded into the flexible Parylene-C film using a batch microfabrication process. Through this fabrication process, the CNTs can be exposed to increase the total sensing area of an electrode. Thus, the flexible CNTs electrode of low impedance...
The long-term goal in the design of Brain-Machine Interfaces is to restore communication and control to unrestrained individuals. One of the great challenges in this effort is to develop implantable systems that are capable of processing the activity of large ensembles of cortical neurons. Here, we present the design, fabrication, and testing of a flexible microelectrode array that can be hybrid-packaged...
We present a process for fabricating a nanoscale probing device for in vitro sensing of neural activity. Single vertical platinum (Pt) nanowires were fabricated on a microelectrode array by focused ion beam (FIB)-chemical vapor deposition (CVD) in order to improve the spatial resolution of recording and to minimize damage to the cells. Electrodes in contact with cells detected prominent spontaneous...
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