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Objective
We investigated the role of chloride homeostasis in seizure progression and development of pharmacoresistant status epilepticus (SE) by pharmacologically targeting the Na‐K‐Cl cotransporter (NKCC1) with bumetanide. We also investigated the ability of bumetanide to restore the efficacy of diazepam following SE.
Methods
Kainic acid (KA)–induced SE in vivo and 0‐Mg2+‐induced seizure‐like...
Purpose: Seizure‐like events (SLEs) induced by 4‐aminopyridine in rat organotypic slices cultures, which are prepared early after birth, are resistant to standard antiepileptic drugs. In this study we tested the hypothesis that pharmacoresistance may be an intrinsic property of the immature brain.
Methods: Frequently recurring SLEs presumably representing status epilepticus were induced by 4‐aminopyridine...
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