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Objective
We investigated the role of chloride homeostasis in seizure progression and development of pharmacoresistant status epilepticus (SE) by pharmacologically targeting the Na‐K‐Cl cotransporter (NKCC1) with bumetanide. We also investigated the ability of bumetanide to restore the efficacy of diazepam following SE.
Methods
Kainic acid (KA)–induced SE in vivo and 0‐Mg2+‐induced seizure‐like...
Early in postnatal development, correlated activity in the hippocampus is characterized by giant depolarizing potentials (GDPs). GDPs are generated by the interplay between glutamate and GABA, which in the immediate postnatal period is depolarizing and excitatory. Here, we review some recent data obtained in our laboratory concerning neuronal signaling at immature MF connections. MF responses were...
Kainate receptors (KARs) are glutamate-gated ion channels assembled from various combinations of GluK1-GluK5 subunits with different physiological and pharmacological properties. In the hippocampus, KARs expressed at postsynaptic sites mediate a small component of excitatory postsynaptic currents while at presynaptic sites they exert a powerful control on transmitter release at both excitatory and...
A robust increase in the functional expression of the neuronal K–Cl cotransporter KCC2 during CNS development is necessary for the emergence of hyperpolarizing ionotropic GABAergic transmission. BDNF-TrkB signaling has been implicated in the developmental up-regulation of KCC2 and, in mature animals, in fast activity-dependent down-regulation of KCC2 function following seizures and trauma. In contrast...
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