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Lithium, the prototypic mood stabilizer, was recently demonstrated to enhance autophagy in cells. Recent hypotheses regarding the source of therapeutic effects of lithium as well as other mood stabilizers and antidepressants suggest that they may stem from increased neuroprotection, cellular plasticity and resilience. Hence it is clearly a possibility that enhanced autophagy may be involved in the...
Repeated stress is an important risk factor for the development of depression. However, the mechanism by which stress influences depression is largely unknown, in part due to the fact that few animal models of repeated stress produce robust changes in depression-like behavior. The purpose of the present study was to characterize the effect of repeated corticosterone (CORT) injections and repeated...
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