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We have studied the effect of the lesion of the dopaminergic innervation of the thalamic reticular nucleus (TRn) on anxiety and motor behaviour. The lesion of the dopamine innervation was produced by the injection of 6-hydroxydopamine into the dorsal part of the thalamic reticular nucleus. The lesion decreased the number of TH (+) cells of the pars compacta of substantia nigra by 33%, without modifying...
The objective of this study was to investigate if selective dopamine depletion within the medial prefrontal cortex modifies the anxiety state in rats. Anxiety was evaluated by using the elevated plus maze test, an anxiety model. Dopamine depletion in the medial prefrontal cortex (79% vs. controls) induced a significantly lower preference to stay on open arms together with a reliably lower frequency...
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