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We investigated the effects of hippocampally kindled seizures on spatial performance of rats in the Morris water maze (MWM). Seizures were elicited with stimulation of field CA1 of dorsal hippocampus 25–45 min prior to daily testing in the water maze. One group of rats was naive to the MWM (acquisition groups), while another group received pretraining in the MWM (retention groups). These groups were...
We used two procedures to assess the spatial learning and memory of rats in the Morris water maze task subsequent to kindling of hippocampal field CA1: (1) seizures were kindled with stimulation of CA1 prior to training in the water maze (acquisition); and (2) maze training was imposed until performance stabilized, seizures were kindled with stimulation of CA1, and then performance in the maze was...
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