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Applications of optical spectroscopy techniques, such as Fourier Transform Infrared (FTIR), Raman, and fluorescence, in biology and medicine have been actively pursued in recent times. Since optical spectroscopic techniques are very sensitive to biochemical composition of the sample under study, they are being pursued as non invasive analytical methodologies. Early transformation from healthy to diseased...
Urinary tract infection diagnosis and antibiogram require a 48 hour waiting period using conventional methods. This results in ineffective treatments, increased costs and most importantly in increased resistance to antibiotics. In this work, a novel method for classifying bacteria and determining their sensitivity to an antibiotic using Raman spectroscopy is described. Raman spectra of three species...
In this paper, we studied skin roughness, so called skin Xerosis, with Raman Spectroscopy technique. The main goal of this study was to determine the features from the Raman spectral data associated with skin xerosis and finally detecting Xerosis from normal skin by using an optimal classification method. The Raman spectral dataset was constructed from two classes of spectral data, 70 spectra of normal...
Many machine learning technique have been employed for the classification of biological cells based on their Raman spectroscopy. Unfortunately, Raman spectroscopy data always has so many attributes that people who deal with them may often confront the problem of "curse of dimensionality". PCA is often used as a linear dimensionality reduction technique for preprocessing Raman data, which...
This paper demonstrates a simple CARS micro-spectrometer based on a single femtosecond Ti:sapphire laser and microstructured optical fibers for frequency compression and frequency conversion. The latest version of our microspectrometer employs a three-pulse geometry, where a pump and a Stokes pulse generates a Raman polarization in the medium which is subsequently probed by a delay pulse. This three-pulse-geometry...
A rapid trapping and detection method for clinical bacteria (Helicobacter pylori, H. pylori) analysis is designed and reported in this study. Different strain of H. pylori can be trapped in 3 dimension dielectrophoresis chip (DEP) under the condition of 20 mM PBS, voltage at 20 Vp-p and frequency at 300 kHz. H. pylori #238(Wild type) presents more and stronger functional group stretching and vibration...
Femtosecond stimulated Raman spectroscopy is a new time-resolved vibrational technique that enables the recording of high resolution (10-20 cm-1) vibrational spectra of dynamic and reactive chemical and biological systems with < 50 fs time resolution.
This paper introduces a method of modeling noninvasive glucose sensing for patients who suffer from diabetes mellitus. The proposed technique involves simulation of light propagation through biological tissue with an embedded photonic crystal. The proposed detection technique is Raman spectroscopy and the use of the photonic crystal enables the enhancement of Raman scattering by engineering the photon...
Raman spectroscopy is a useful tool to investigate the molecular composition of biological samples. Source separation methods can be used to efficiently separate dense informations recorded by Raman spectra. Distorting effects such as fluorescence background, peak misalignment or peak width heterogeneity break the linear and instantaneous generative model needed by the source separation methods. Preprocessing...
Frequent measurement of blood glucose is crucial for diabetic patients in managing the glucose level and thus reducing the severe complications associated with the disease. Raman spectroscopy is one of the non-invasive optical techniques that have been proposed for physiological glucose measurement. In this study, we used a relatively inexpensive, compact and portable Raman system which can be made...
Laser-induced fluorescence and Raman spectroscopy of serum for detect colon cancer was investigated in this paper. The difference to serum spectrum was discovered. Three Raman peaks were consistently observed from normal blood serum emission using 488.0 nm and 514.5 nm excitation of an Ar-ion laser. While no Raman peak or slight Raman peaks were detected from colon cancer's cases. In addition, the...
Laser-induced fluorescence spectroscopy (LIF) and Raman spectrum of serum for diagnosis of rectum cancer were investigated by criteria of three parametric modes in this paper. The aim of this study was in an attempt to find the difference normal and rectum cancer cases, therefore 89 rectum cancer samples were measured using fluorescence and Raman spectrum. The experimental result showed that there...
We could get valuable information about various diseases by analyzing urine of patients. For the diabetics, it has been very important to know the glucose concentration in their urine. Until now, there have been many methods to estimate the concentration but they were invasive and annoyed patients. The low-resolution Raman spectroscopy (LRRS) could be an alternative method to be non-invasive and unconscious...
As an effort for the development of the nonintrusive measurement system, Raman spectroscopy was applied for the urinalysis. By using Raman spectroscopy, the concentration of the urine components could be measured. As a multivariate method, the partial least squares method was performed. When composing a calibration model, the determination of the appropriate number of factors was very important for...
We report on an innovative optical sensor based on the combination of optical tweezers and Raman Spectroscopy that is highly sensitive and selective for fast detection and identification of single biological and nonbiological particles.
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