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Colorectal cancer (CRC) is one of the most common malignant tumors. One of the factors increasing the risk of its occurrence may be the reduced efficiency of repairing DNA damage, both nuclear and mitochondrial. The main mechanism for repairing oxidative damage is the BER system (in mitochondria mtBER), whose key proteins NEIL1, NEIL2, OGG1, MUTYH, APE1 and LIG3 obtain full efficiency only at the...
Objective: To study the expression of angiopoietin-1 (Ang-1), angiopoietin-2 (Ang-2) and the angiopoietin receptor (Tie-2) in colorectal cancer tissue, and analyze the correlation between their expression levels in colorectal cancer tissue and the histological differentiation of colorectal cancer; and to discuss their roles in the progression of colorectal cancer to provide new targets for the clinical...
Copy-number variation (CNV) constitutes a large proportion of total genomic variation and is increasingly recognized to be an extremely important risk factor for cancer. To examine the role of CNVs in glioblastoma, a genome-wide association study of CNVs in glioblastoma was conducted by assaying 221 tumor tissues and 28 normal tissues samples from primary glioblastoma multiform patients in TCGA project...
scFv (single-chain Fv fragment) is the gene engineered antibody employed widely in at present. Recently there have been some progress on colorectal cancer diagnosis and treatment-oriented with scFv as carrier, but it is differential on affinity and anti-tumor activity of scFv with that of derived factor. Proper linker could make scFv have more suitable biological activity on clinical application....
Abstract-In this paper we discuss methylation sequencing of DNA target in E-Cadherin gene in head and neck cancer and colorectal cancer by bisulfite-PCR. Bisulfite converted genomic DNA were purified prior to amplification by PCR. Primers are designed to amplify both methylated and unmethylated strands of target DNA sequence. Status of methylation was ascertained by native PAGE. Intriguingly, we have...
In the post-genome era, disease-relevant gene finding and prioritization have focused on genome-wide association studies and molecular interaction networks, due to their power in characterizing the functions of genes/proteins in genomics and network biology contexts. In this paper, we describe a simple yet generic computational framework based on protein interaction networks to perform and evaluate...
Systemic chemotherapy is widely used for treatment of metastatic colorectal cancer (CRC). However, many CRC patients show poor response to chemotherapy and suffered from toxicities. Thus, prediction of chemotherapy response is very important in effective therapy. In the present study, we investigated whether chemotherapy response of CRC can be predicted by nano-assisted laser desorption/ionization...
Multivariate experiments and genomics studies applied to mammalian cells often produce lists of genes or proteins altered under treatment/disease vs. control/normal conditions. Such lists can be identified in known protein-protein interaction networks to produce subnetworks that "connect" the genes or proteins from the lists. Such subnetworks are valuable for biologists since they can suggest...
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