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Objective : To test the expression of PDGFR-β in colorectal cancer stroma, and evaluate the relationship to lymphangiogenesis. Methods: Applying Immunohistochemistry SP method, the expression of PDGFR-β in 90 patients with colorectal cancer and 20 normal tissues. Marked by D2–40, lymphatic microvessel density (LMVD) was counted. The expression of PDGFR-β and its relationship to LMVD and clinicopathologic...
Identification of genes and pathways involving in diseases and physiological conditions is a major task in systems biology. In this study, we develop a new non-parameter Ising model to integrate protein-protein interaction network and microarray data for identifying differentially expressed (DE) genes. We also propose a simulated annealing algorithm to find the optimal configuration of the Ising model...
Background: Although clinical significance of serum p53 Abs (s-p53 Abs) in cancer patients has been studied during the past few years, how to detect it effectively is a crucial issue. Methods: wild-type p53 protein (wt p53) and phage-displayed peptide were prepared. Three types of enzymelinked immunosorbent assays (ELISA) methods were constructed and a hybrid antigen-ELISA approach was attempted....
Different genes have different biological functions, these functions interactions between genes, moreover they play an important role in gene regulatory networks. In the recent cancer research field, a definite conclusion for the regulatory mechanisms of tumor genesis and metastasis has yet been found. Therefore we will apply oncogenes and suppressor genes from ovarian carcinoma micro array data analysis,...
Purpose To investigate the expression of small G protein R-Ras in breast cancer and to explore the significance of R-Ras, expression in the carcinogensis and development of breast carcinoma, and we also analysed the correlation of R-Ras expressions with ER, PR. Methods Real time quantitative reverse transcription polymerase chain reaction (RQ-RT-PCR) technique was applied for detecting R-Ras expression...
Curcumin, the most active constituent of turmeric, is currently one of the major anticance new drugs and has been reported to enhance Heme Oxygenase-1(HO-1) in human brain when oxidative stress occur. Keeping the balance of HO-1 and HO-2 plays an important role in the brain. However, few researches study the effects of curcumin on the two isoenzymes of HO. Here we investigated the effects of curcumin...
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