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A new concept aiming to improve surgical outcome by providing real-time surgical feedback on tumor margin delineation is presented. We are using a novel multispectral imaging system for real time measurement of fluorescence probes with molecular specificity to tumor biomarkers. Mice bearing xenograft tumors were used to simulate surgical operations of tumor excision guided by real time fluorescence...
Bioluminescence of luciferase-expressing cells in live animals is a promising technique for image guided tumor resection. However, requiring exact optical tissue parameters is an underlying problem of diffusion equation when recovering bioluminescent images of luciferase activity within a volume using emission optical signal data from internal light sources. In this paper, an equivalence method based...
Bioluminescence tomography (BLT) is a novel in vivo technique which may reveal the molecular and cellular activity at the whole-body level in small animal studies. In order to reconstruct bioluminescence sources accurately, it is necessary to incorporate all types of a priori information available and develop novel reconstruction algorithms. In this paper, a multi-scale method is proposed for BLT...
We have developed a new method for in vivo functional imaging of the mouse brain using a dedicated CMOS image sensor chip. The image sensor has 176times144-pixels with pixel size of 7.5times7.5 mum 2. A novel packaging process is developed to enable on-chip fluorescence imaging. The sensor chip is attached to a flexible polyimide substrate and sealed in epoxy. A thin-film resist is spin-coated directly...
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