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An experimental research of the drug pyrazinamide is analyzed and tested with potentiometric method. By understanding the biomechatronic system, consisted of a mechanism of action of the drug Pyrazinamide in a biological system, and an electrical signals, voltametric measures, a method to detect resistance to this specific drug is developed and tested firstly in vitro, then in cultures and finally...
Ovarian cancer is the leading cause of death in gynecological cancers. Carboplatinum-based therapy is the standard treatment choice for ovarian cancer. However, a majority of the patients develop resistance to carboplatinum fairly rapidly hence there is a clinical need for early predictors of carboplatinum resistance. While there are a few indicative gene markers, they have poor sensitivity and specificity...
H5N1 has been identified as the most pathogenic strain of avian flu, and therefore has been the most studied in prospective vaccine strategies. The grim reality of material and personnel shortage during a pandemic renders all of the currently proposed technologies inadequate for rapid mass vaccination. The long term goal of this project is to develop a transdermal patch containing a nanoencapsulated...
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